Notch1 variants associated with cardiovascular disease

Details Notch1 variants associated with cardiovascular disease Notch1 variants associated with cardiovascular disease

2004-12-17

2009-12-08

Schultz, J D (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100

Reexamination Certificate

active

07629121

ABSTRACT:
Human individuals at increased risk for vascular pathology are identified by determining whether the individuals' genome comprises a Notch1 allele predetermined to be associated with an increased risk for vascular pathology. Notch1 alleles are identified as being associated with increased risk for vascular pathology by detecting the presence of a same Notch allele in a plurality of persons with increased risk for vascular pathology.

REFERENCES:
Hacker et al; Gut, 1997, vol. 40, pp. 623-627).
Pennisi, Science, 1998; 281 (5384):1787-1789.
Mohamed et al, Biophysical and Biochemical research communications, vol. 345, pp. 1460-1465, 2006.
Rosenhek, Circulation, vol. 110, pp. 1291-1295, 2004.

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