Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Reexamination Certificate
2005-05-03
2005-05-03
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
C514S003100, C435S373000, C530S350000
Reexamination Certificate
active
06887475
ABSTRACT:
The present invention relates to the use of therapeutic compounds in the modification of T-cells, T-cell-antigen presenting cell (APC) interactions and the interaction between pathogenic organism and immunocompetent cells of a host. In particular, it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, asthma and infectious diseases.
REFERENCES:
patent: 6004924 (1999-12-01), Ish-Horowicz et al.
patent: WO 9219734 (1992-11-01), None
patent: WO 9407474 (1994-04-01), None
patent: WO 9519779 (1995-07-01), None
patent: WO 9521258 (1995-08-01), None
patent: WO 9627610 (1996-09-01), None
patent: WO 9701571 (1997-01-01), None
patent: WO 9711716 (1997-04-01), None
patent: WO 9719172 (1997-05-01), None
Jones, ND et al. Journal of Immunology (2001) 166:2824-2830.*
Tufveson, G et al. Immunological Reviews (1993) 136:99-109.*
Artavanis-Tsakonas et al. (1995) Science 268:225-232.*
Jaleco et al. (2001) Journal of Experimental Medicine 194(7):F43-46.*
Janeway et al. (1999) Immunobiology Fourth Edition, Garland Press, NY pg. 246.*
Robey et al.. “An Activated Form of Notch Influences the Choice Between CD4 and CD8 T Cell Lineages.” Cell, vol. 87, Nov. 1, 1996. pp. 483-492.
Artavanis-Tsakonas et al., “Notch Signaling,” Science. vol. 268, Apr. 14, 1995, pp. 225-232.
Qin et al., “Infectious Transplantation Tolerance,” Science, vol. 259, Feb. 12, 1993, pp. 974-977.
Isobe et al., “Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1, ” Science. vol. 255, Feb. 18, 1992, pp. 1125-1127.
Robey, “Notch in Vertebrates,” Current Opinion in Genetics and Development, vol. 7, 1997, pp. 551-557.
Medzhitov et al., “A Human Homologue of the Drosophila Toll Protein Signals Activation of Adaptive Immunity,” Nature, Jul. 1997, pp. 394-396.
“Peptide(s) Encoded by Human Genes Delta-1 and Serrate-1 Suppress Proliferation and Differentiation of Undifferentiated Human Blood Cell,” Derwent abstract based on Japanese Appln. No. 97-298100, May 29, 1997.
Hoyne, G.F., “Notch Signaling in the Immune System,” Journal of Leukocyte Biology, vol. 74, pp. 971-81, 2003.
Hoyne, G.F., et al., “Serrate 1-Induced Notch Signaling Regulates The Decision Between Immunity and Tolerance Made by Peripheral CD4+Cells”, International Immunology, vol. 12, No. 2, pp. 177-185, 1999.
Hoyne, G.F., et al., “Linked Suppression in Peripheral T Cell Tolerance to the House Dust Mite Derived Allergen Der p 1”, Int'l Archives of Allergy and Immunology, vol. 118, pp. 122-124, 1999.
Hoyne, G.F., et al., “T-Cell Regulation of Peripheral Tolerance and Immunity: The Potential Role for Notch Signalling”, Immunology, vol. 100, pp. 281-288, 2000.
Hoyne, G.F., et al., “Notch Signalling in the Regulation of Peripheral Immunity”, Immunological Reviews, vol. 182, pp. 215-227, 2001.
McKenzie, G.J., et al., “Notch Signalling in the Regulation of Peripheral T-cell Function”, Seminars in Cell & Development Biology, vol. 14, pp. 127-134, 2003.
Dallman, M.J., et al., “Notch Signalling in the Peripheral Immune System”, Novartis Foundation Symposium, vol. 252, pp. 268-278, 2003.
Wong, K.K., et al., “Notch Litigation by Delta 1 Inhibits Peripheral Immune Responses to Transplantation Antigens by CD8+Cell-dependent Mechanism”, The Journal of Cilnical Investigation, vol. 112, No. 11, pp. 1741-1750, Dec. 2003.
Hasserjian, R.P., et al., “Modulated Expression of Notch 1 During Thymocyte Development”, Blood, vol. 88, No. 3, pp. 970-976, Aug. 1996.
Lee et al. (1996) “GP300SCA is not a high affinity Notch ligand”, Biochem. and Biophys. Res. Comm. 225:720-25
Lindell et al. (1995) “Jagged: A mammalian ligand that activates Notch-1”, Cell 80:909-17.
Dallman Margaret Jane
Hoyne Gerard Francis
Lamb Jonathan Robert
Frommer Lawrence & Haug
Kowalski Thomas J.
Lorantis Limited
VanderVegt F. Pierre
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