Notch

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C424S278100, C424S810000

Reexamination Certificate

active

07399741

ABSTRACT:
The present invention relates to the use of therapeutic compounds in the modification of T-cell, T-cell-antigen presenting cell (APC) interactions and the interactions between pathogenic organisms and immunocompetent cells of a host. In particular it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligands and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, and asthma and infectious diseases.

REFERENCES:
patent: 6004924 (1999-12-01), Ish-Horowicz et al.
patent: WO 92/19734 (1992-11-01), None
patent: WO 94/07474 (1994-04-01), None
patent: WO 95/19779 (1995-07-01), None
patent: WO 95/21258 (1995-08-01), None
patent: WO 96/27610 (1996-09-01), None
patent: WO 97/01571 (1997-01-01), None
patent: WO 97/11716 (1997-04-01), None
patent: WO 97/19172 (1997-05-01), None
Atkinson, MA et al. Nature Medicine [1999] 5(6):601-604.
Tisch, R et al. Proc. Nat. Acad. Sci. (USA). [1994] 91:437-438.
Hoyne, G.F., et al., “Serrate 1-Induced Notch Signaling Regulates The Decision Between Immunity And Tolerance Made By Peripheral CD4+T Cells”, International Immunology, vol. 12, No. 2, pp. 177-185, 1999.
Hoyne, G.F., et al., “Linked Suppression in Peripheral T Cell Tolerance to the House Dust Mite Allergen Der p 1”, Int'l Archives of Allergy and Immunology, vol. 118, pp. 122-124, 1999.
Hoyne, G.F., et al., “T-Cell Regulation of Peripheral Tolerance and Immunity: The Potential Role for Notch Signalling”, Immunology, vol. 100, pp. 281-288, 2000.
Hoyne, G.F., et al., “Notch Signalling in the Regulation of Peripheral Immunity”, Immunological Reviews, vol. 182, pp. 215-227, 2001.
McKenzie, G.J., et al., “Notch Signalling in the Regulation of Peripheral T-cell Function”, Seminars in Cell & Development Biology, vol. 14, pp. 127-134, 2003.
Dallman, M.J., et al., “Notch Signalling in the Peripheral Immune System”, Novartis Foundation Symposium, vol. 252, pp. 268-278, 2003.
Wong, K.K., et al., “Notch Litigation by Delta 1 Inhibits Peripheral Immune Responses to Transplantation Antigens by CD8+Cell-dependent Mechanism”, The Journal of Clinical Investigation, vol. 112, No. 11, pp. 1741-1750, Dec. 2003.
Hasserjian, R.P., et al., “Modulated Expression of Notch 1 During Thymocyte Development”, Blood, vol. 88, No. 3, pp. 970-976, Aug. 1996.
Jones, ND et al. Journal of Immunology (2001) 166:2824-1830.
Tufveson, G. et al. Immunological Reviews (1993) 136: 99-109.
Artavanis-Tsakonas et al. (1995) Science 268:225-232.
Jaleco et al (2001) Journal of Experimental Medicine 194 (7): F43-46.
Janeway et al. (1999) Immunobiology Fourth edition, Garland Press, NY, p. 246.
Hoyne, G.F., “Notch Signaling in the Immune System,” Journal of Leukocyte Biology, vol. 74, pp. 971-981, 2003.
Robey et al., “An Activated Form of Notch Influences the Choice Between CD4 and CD8 T Cell Lineages.” Cell, vol. 87. Nov. 1, 1996. pp. 483-492.
Artavanis-Tsakonas et al., “Notch Signaling.” Science. vol. 268. Apr. 14, 1995. pp. 225-232.
Qin et al., “Infectious Transplantation Tolerance.” Science, vol. 259, Feb. 12, 1993. pp. 974-977.
Isobe et al., “Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1,” Science, vol. 255, Feb. 18, 1992. pp. 1125-1127.
Robey, “Notch in Vertebrates.” Current Opinion in Genetics and Development, vol. 7, 1997, pp. 551-557.
Medzhitov et al., “A Human Homologue of the Drosophila Toll Protein Signals Activation of Adaptive Immunity.” Nature, Jul. 1997, pp. 394-396.
“Peptide(2) Encoded by Human Genes Delta-1 and Serrate-1 Suppress Proliferation and Differentiation of Undifferentiated Human Blood Cell,” Derwent abstract based on Japanese Appln. No. 97-298100. May 29, 1997.
Berthold Bettenhausen, et al., Transient And Restricted Expression During Mouse Embryogenesis of DIII, A Murine Gene Closely Related To Drosophila Delta, Development (1995) vol. 121, p. 2407-2418.
Ajay Chitnis, et al., Primary Neurogenesis In Xenopus Embryos Regulated By A Homologue Of The Drosophila Neurogenic Gene Delta, Nature (1995) vol. 375, p. 761-766.
GenBank Accession No. L42229.
Domingos Henrique, et al., Expression Of A Delta Homologue In Prospective Neurons In The Chick, Nature (1995) vol. 375, p. 787-790.
GenBank Accession No. U26590.
Claire E. Lindsell, et al., Jagged: A Mammalian Ligand That Activated Notch1, Cell (1995) vol. 80, p. 909-917.
Gen Bank Accession No. L38483.
J.A. Harper, et al., Notch Signaling In Development And Disease, Clin. Genet. (2003) vol. 64, p. 461-472.
Takahiro Suzuki, et al., Notch Signaling In Hematopoietic Stem Cells, International Journal of Hematology (2005) vol. 82, p. 285-294.
La Motte-Mohs Ross, N. et al., FASEB Journal, vol. 18, Abstracts 83-34.

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