Nornicotine enantiomers for use as a treatment for dopamine rela

Details Nornicotine enantiomers for use as a treatment for dopamine rela Nornicotine enantiomers for use as a treatment for dopamine rela

1996-11-15

1998-07-07

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

057769575

ABSTRACT:
Optically active nornicotine compounds as a treatment for dopamine-related conditions and disease states. Such disease states include the treatment of myasthenia gravis, Parkinson's disease, Alzheimer's disease, schizophrenia, eating disorders, ulcers, drug addiction and as a substitute for psycho-stimulant self-administration.

REFERENCES:
patent: 4321387 (1982-03-01), Chavdarian et al.
patent: 4442292 (1984-04-01), Edwards, III
patent: 4965074 (1990-10-01), Lesson
patent: 4966916 (1990-10-01), Abood
patent: 5138062 (1992-08-01), Osdene et al.
patent: 5214060 (1993-05-01), Caldwell et al.
patent: 5223497 (1993-06-01), Gawin et al.
patent: 5227391 (1993-07-01), Caldwell et al.
patent: 5232933 (1993-08-01), Lippiello et al.
patent: 5242934 (1993-09-01), Lippiello et al.
patent: 5276043 (1994-01-01), Lippiello et al.
patent: 5278045 (1994-01-01), Tam
patent: 5278176 (1994-01-01), Lin
patent: 5594011 (1997-01-01), McDonald et al.
"The Pharmacological Basis of Therapeutics", Fourth Edition, A. Goodman et al, 1970.
"The Pharmacological Basis of Therapeutics", Eighth Edition, Gilman et al, 1990.
Molecular Pharmacology, E.C. Hume et al, vol. 14, pp. 737-750, 1990.
Pharmocological Biochemical Behavior, Wegner et al, vol. 46:435-443, 1993.
"Principles of Drug Action", Second Edition, Goldstein et al, 1974.
Chemical Abstracts 122:233216, "Minor Alkaloids of Tabacco Release
Chemical Abstracts 119:108808, "S(-)-Nornicotine Increases Dopamine Release in a Calcium-Dependent Manner From Superfused Rat Striatal Slices", Dwoskin et al, 1993.
Ricky Yeargan et al., "Tissue partitioning of cadmium in transgenic tobacco seedlings and field grown plants expressing the mouse metallothionein 1 gene", Transgenic Research 1, 261-267 (1992).
Indu B. Maiti et al., "Properties of transgenic plants that express a functional potyvirus P1 proteinase gene", 1995, pp. 1-18.
Indu B. Maiti et al., "Properties of transgenic plants that express a functional potyvirus p1 proteinase gene or a fused CP gene", 8th International Congress Molecular Plant-Microbe Interactions, Jul. 14-19, 1996 (Abstract #B-78).
Indu B. Maiti et al., "Expression of the Tobacco vein mottling virus nuclear inclusion protein (Na) gene in tobacco", J. Cell. Biochem. Supplement 16F, (Abstract #Y213).
Indu B. Maiti et al., "Seed-Transmissable Expression of Mammalian Metallothionein in Transgenic Tobacco", Biochemical and Biophysical Research Communications, vol. 150, No. 2, 1988, pp. 640-647.
Indu B. Maiti et al., "Expression of the Tobacco Vein Mottling Virus Coat Protein (CP) and Cylindrical Inclusion Proteion (C1) Genes in Tobacco", 3rd International Congress Int. Soc. Plant Mol. Biol. meeting Oct. 6-11, 1991 (Abstract #1154).
Indu B. Maiti et al., "Plants that Express a Potyvirus Proteinase Gene are Resistant to Virus Infection", Proc. Natl. Acad. Sci., vol. 90, pp. 6110-6114 (1993).
Indu B. Maiti et al., "Light Inducible and Tissue-Specific Expression of a Chimeric Mouse Metallothionein cDNA Gene in Tobacco", Plant Science, 76 (1991) pp. 99-107.
Indu B. Maiti et al., "Inheritance and Expression of the Mouse Metallothionein Gene in Tobacco", Plant Physiol. (1989) 91, pp. 1020-1024.
Indu B. Maiti et al., "Developing Genetically Engineered Disease, Pest and Herbicide Resistance in Tobacco", Recent Advances in Tobacco Science, vol. 18, Sep. 27-30, 1992, pp. 45-68.
Franklin et al., "Genetic Transformation of Peanut and Bean Callus Via Agrobacterium-Mediated DNA Transfer", Jour. of Cell. Bio. Abstract Y141, Apr. 3-16, 1992, p. 214.
Indu B. Maiti et al., "Multiple Potyvirus Genes do not Confer Protection Upon Plants Additively", 4th Congress of ISPMB meeting, Jun. 19-24, 1994 (Abstract #1533).
Indu B. Maiti et al., "Promoter/leader deletion analysis and plant expression vectors with the figwort mosaic virus (FMV) full length transcript (FLt) promoter containing single or double enhances domains", Transgenic Research 5.
G. Jason Smith et al., "Expression of Heterologous Genes Following Electroporation of the Marine Diatom Skeletonema Costatum", Plant Physiology, Abstract 803, Jun. 1995, vol. 108, No. 2.
Bird et al., "Transgenic Plants With Increased Solids Content", Chemical Abstracts, vol. 119, Abstract No. 19725In, 1993, p. 260.
Franklin et al., "High Expression of a Foreign Gene in Transformed Bean Callus", In Vitro Cellular & Development Biology, Mar. 19, 1992, vol. 28, No. 2, Abstract P-1119.
Rie Terada et al., "Expression of CaMV35S-GUS gene in transgenic rice plants", Molecular & General Genetics, vol. 220, pp. 389-392, 1990.

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