Norbornane type ester hydrolase from Acetobacter pasteurianus

Details Norbornane type ester hydrolase from Acetobacter pasteurianus Norbornane type ester hydrolase from Acetobacter pasteurianus

1994-04-22

1996-01-16

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435196, 435823, C12N 918, C12N 916

Patent

active

054847257

ABSTRACT:
A norbornane type ester hydrolase that enantio-selectively hydrolyzes a (.+-.)-exo-norbornane type ester represented by Formula I is provided: ##STR1## wherein R is acyl, and A and B are hydrogens, respectively, or where A and B are absent, resulting in a carbon-carbon double bond between the carbons to which A and B are attached in Formula I. The norbornane type ester hydrolase has an optimal pH of approximately 8 and a stable pH range of approximately 6 to 8.

REFERENCES:
patent: 4075405 (1978-02-01), Takahashi et al.
patent: 5124462 (1992-06-01), Ohtani et al.
patent: 5270206 (1993-12-01), Saccomano
Meltz et al., Tetrahedron Lett. 33:1201-1202 (1992).
Th. Oberhauser et al., "Enzymatic Resolution of Norbornane-Type Esters", Tetrahedron, 43 pp. 3931-3944 (1987).
M. Narisada et al., "Synthesis and in Vitro Activity of Various Derivatives of a Novel Thromboxane Receptor Antagonist, (.+-.)-(5Z)-7-[3-endo-[(Phenylsulfonyl) amino] bicyclo [2.2.1] hept-2-exo-yl] heptenoic Acid", J. Med. Chem., 31, pp. 1847-1854 (1988).

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