Norbornane type ester hydrolase

Details Norbornane type ester hydrolase Norbornane type ester hydrolase

1995-06-01

1997-11-11

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

536 232, 536 237, 435 691, 43525233, 4353201, C12N 918, C12N 120, C07H 2104, C12P 2106

Patent

active

056862857

ABSTRACT:
A norbornane type ester hydrolase that enantio-selectively hydrolyzes a (.+-.) -exo-norbornane type ester represented by Formula I is provided: ##STR1## wherein R is acyl, and A and B are hydrogens, respectively, or where A and B are absent, resulting in a carbon-carbon double bond between the carbons to which A and B are attached in Formula I. The norbornane type ester hydrolase has an optimal pH of approximately 8 and a stable pH range of approximately 6 to 8.

REFERENCES:
patent: 4075405 (1978-02-01), Takahashi
patent: 5124462 (1992-06-01), Ohtani
patent: 5270206 (1993-12-01), Saccomano et al.
M. Meltz & N. Saccomano, "Lipase Mediated Optical Resolution of Bicyclic Secondary Carbinols", Tetrahedron Lett., 33, pp. 1201-1202 (1992).
M. Narisada et al., "Synthesis and In Vitro Activity of Various Derivatives of a Novel Thromboxane Receptor Antagonist, hept-2-exo-yl! heptenoic Acid", J. Med. Chem., 31, pp. 1847-1854 (1988).
Th. Oberhauser et al., "Enzymatic Resolution of Norbornane-Type Esters", Tetrahedron, 43, pp. 3931-3944 (1987).

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