Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-12-11
2007-12-11
Graser, Jennifer E. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S256100, C424S185100, C530S350000, C530S300000
Reexamination Certificate
active
10807746
ABSTRACT:
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain ofHaemophilus influenzae(NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.
REFERENCES:
Wood (Guide to Molecular Cloning Techniques. vol. 152. 1987. Section IX. Chapter 49, pp. 443-447).
Genbank Accession No. P45285 Fleischmann, et al., “Peptide Transport Periplasmic Protein sapA Precursor” (Sep. 13, 2005).
Fleischmann, et al., “Whole-Genome Random Sequence and Assembly ofHaemophilus influenzaeRd”, Science 269: 496-512 (Jul. 28, 1995).
Genbank Accession No. U32837 Fleischmann, et al., “Haemophilus influenzaeRd KW20 section 152 of 163 of the complete genome” (Jun. 2, 2004).
Barenkamp, et al., Outer Membrane Protein and Biotype Analysis of Pathogenic NontypableHaemophilus influenzae, Infection and Immunity, 36(2): 535-540 (May 1982).
Musser, et al., Genetic Relationships of Serologically Nontypable and Serotype b Strains ofHaemophilus influenzae, Infection and Immunity, 52(1): 183-191 (Apr. 1986).
Spinola, et al., Epidemiology of Colonization by NontypableHaemophilus influenzaein Children: A Longitudinal Study,Journal of Infectious Diseases, 154(1): 100-109 (Jul. 1986).
Bakaletz, et al., Frequency of Fimbriation of NontypableHaemophilus influenzaeand Its Ability To Adhere to Chinchilla and Human Respiratory Epithelium,Infection and Immunity, 56(2): 331-335 (Feb. 1988).
Parra-Lopez, et al., Molecular Genetic Analysis of a Locus Required For Resistance to Antimicrobial Peptides inSalmonella typhimurium, EMBO12(11): 4053-4062 (1993).
Bakaletz, et al., Modeling Adenovirus Type 1-Induced Otitis Media in the Chinchilla: Effect on Ciliary Activity and Fluid Transport Function of Eustachian Tube Mucosal Epithelium,Journal of Infectious Diseases, 168: 865-872 (1993).
Suzuki, et al., Synergistic Effect of Adenovirus Type 1 and NontypeableHaemophilus influenzaein a Chinchilla Model of Experimental Otitis Media,Infection and Immunity, 62(5): 1710-1718 (May 1994).
Giebink, Immunology: Promise of New Vaccines, Ped. Infect Dis. J., 13(11): 1064-1068 (1994).
Karma, et al., Immunological Aspects of Otitis Media: Present Views on Possibilities of Immunoprophylazis of Acute Otitis Media in Infants and Children,International Journal of Pediatric Otorhinolaryngology, 32 (Suppl.): S127-S134 (1995).
DeMaria, et al., Immunization with Outer Membrane Protein P6 from NontypeableHaemophilus influenzaeInduces Bactericidal Antibody and Affords Protection in the Chinchilla Model of Otitis Media,Infection and Immunity, 64(12): 5187-5192 (Dec. 1996).
Jerome, Role of NontypeableHaemophilus influenzaein Pediatric Respiratory Tract Infections,Ped. Infect Dis. J., 16(2): S5-S8 (Feb. 1997).
Bakaletz, et al., Relative Immunogenicity and Efficacy of Two Synthetic Chimeric Peptides of Fimbrin as Vaccinogens Against Nasopharyngeal Colonization by NontypeableHaemophilus infulenzaein the Chinchilla,Vaccine, 15(9): 955-961 (Jun. 1997).
Holmes, et al., Adherence of Non-TypeableHaemophilus influenzaePromotes Reorganization of the Actin Cytoskeleton in Human or Chinchilla Epithelial Cells in vitro,Microblal Pathogenesis, 23: 157-166 (1997).
López-Solanilla, et al., Inactivation of thesapAtosapFLocus ofErwinia chrysanthemiReveals Common Features in Plant and Animal Bacterial Pathogenesis,Plant Cell, 10: 917-924 (Jun. 1998).
Bakaletz, et al., Protection against Development of Otitis Media Induced by NontypeableHaemophilus influenzaeby Both Active and Passive Immunization in a Chinchilla Model of Virus-Bacterium Superinfection,Infect. Immunity67(6): 2746-2762 (Jun. 1999).
Novotny, et al., Epitope Mapping of the Outer Membrane Protein P5-Homologous Fimbrin Adhesin of NontypeableHaemophilus influenzae, Infection and Immunity, 68(4): 2119-2128 (Apr. 2000).
Kennedy, et al., Passive Transfer of Antiserum Specific for Immunogens Derived from a NontypeableHaemophilus influenzaeAdhesin and Lipoprotein D Prevents Otitis Media after Heterologous Challenge,Infection and Immunity, 68(5): 2756-2765 (May 2000).
Black, et al., Efficacy, Safety and Immunogenicity of Heptavalent Pneumococcal Conjugate Vaccine in Children,Ped. Infect. Dis. J., 19(3): 187-195 (2000).
Eskola, et al., Potential of Bacterial Vaccines in the Prevention of Acute Otitis Media,Ped. Infect. Dis. J., 19(5): S72-S78 (2000).
Eskola, et al., Efficacy of A Pneumococcal Conjugate Vaccine Against Acute Otitis Media,N. Engl. J. Med., 344(6): 403-409 (Feb. 2001).
Poolman, et al., Developing a NontypeableHaemophilus influenzae(NTHi) Vaccine,Vaccine, 19: S108-S115 (2001).
Snow, Progress in the Prevention of Otitis Media Through Immunization,Otology&Neurotology, 23(1): 1-2 (2002).
Genebank Accession No. Q9K1VA, Hemoglobin Binding Protein A Precursor, Oct. 16, 2001.
Parra-Lopez et al., ASalmonellaProtein that is Required for Resistance to Antimicrobial Peptides and Transport of Potassium,EMBO J. 13(17): 3964-3972 (1994).
Bakaletz et al., Evidence for Transduction of Specific Antibodies into the Middle Ear of Parenterally Immunized Chinchillas after an Upper Respiratory Infection with AdenovirusClin. Diag. Lab. Immunol. 4(2): 223-225 (Mar. 1997).
McCoy et al., Identification ofProteas mirabiliswith Increased Sensitivity AntiMicrobial Peptides,Antimicrob. Agents Chemother. 45(7): 2030-2037 (Jul. 2001).
Bakaletz Lauren O.
Munson, Jr. Robert S.
Children's Hospital, Inc.
Graser Jennifer E.
LandOfFree
Nontypeable Haemophilus influenzae virulence factors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nontypeable Haemophilus influenzae virulence factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nontypeable Haemophilus influenzae virulence factors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3867951