Nontypeable Haemophilus influenzae virulence factors

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S185100, C424S190100

Reexamination Certificate

active

07901692

ABSTRACT:
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain ofHaemophilus influenzae(NTHi). The invention also relates to the NTHi sap operon genes and the polypeptides encoded by these polynucleotide sequences. The invention also relates to a novel 110 kDa NTHi outer membrane protein and the polynucleotide that encodes this outer membrane protein. Methods of screening for NTHi infection, and treating and preventing NTHi related disorders are also contemplated.

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