Nontoxic pseudomonas aeruginosa polysaccharide-tetanus toxoid an

Details Nontoxic pseudomonas aeruginosa polysaccharide-tetanus toxoid an Nontoxic pseudomonas aeruginosa polysaccharide-tetanus toxoid an

1986-08-04

1988-09-13

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530402, 530403, 530405, 424 92, 514 54, C07K 1700, A61K 39104

Patent

active

047711272

ABSTRACT:
Polysaccharide-protein conjugates were synthesized utilizing polysaccharide derived from hydrolyized Pseudomonas aeruginosa lipopolysacharide covalently coupled to either tetanus toxoid or P. aeruginosa toxin A, utilizing a spacer molecule and a coupling agent. Conjugates produced in such a manner possess a molecular weight of greater than 350,000, are nontoxic and non-pyrogenic, and upon immunization of animals induced protective anti-LPS antibody and antibody which neutralizes the lethal effect of tetanus toxin or toxin A. The polysaccharide-tetanus toxoid conjugate and polysaccharide-toxin A conjugate are safe and immunogenic when parenterally administered to humans.

REFERENCES:
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4619828 (1986-10-01), Gordon
patent: 4663160 (1987-05-01), Tsay et al.
patent: 4693891 (1987-09-01), Collins et al.
patent: 4707543 (1987-11-01), Zollinger et al.
Seid et al., JBC 1981, pp. 7305-7310.

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