Nontoxic, immunologically crossreactive toxin A protein from Pse

Details Nontoxic, immunologically crossreactive toxin A protein from Pse Nontoxic, immunologically crossreactive toxin A protein from Pse

1981-12-30

1984-09-11

Hazel, Blondel

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 88, 424 92, 435 68, 435253, C07G 700, A61K 39104, C12P 2100, C12N 120

Patent

active

044709242

ABSTRACT:
A nontoxic, immunologically crossreactive toxin A protein produced by a PAO-PR1 mutant strain of Pseudomonas aeruginosa. The protein, in activated form, has substantially no adenosine diphosphate-ribosylating activity, and is nontoxic to cells known to be susceptible to the parent PAO-1 strain of Pseudomonas aeruginosa from which strain PAO-PR1 was derived. The nontoxic toxin A protein is immunologically indistinguishable from, and has a molecular weight similar to, native toxin A protein produced by the PAO-1 strain.

REFERENCES:
patent: 4285936 (1981-08-01), Pier et al.
Chemical Abstracts, vol. 91, p. 166, Abst. No. 84300n, 1979.
Chemical Abstracts, vol. 90, p. 143, Abst. No. 133715, 1979.
Iglewski, B., et al., Proc. Nat. Acad. Sci., vol. 72, pp. 2284-2288, 1975.
Cryz, Jr., et al., Proc. Natl. Acad. Sci., vol. 77, pp. 7199-7203, Dec. 1980.

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