Nontoxic extract of larrea tridentata and method of making the s

Details Nontoxic extract of larrea tridentata and method of making the s Nontoxic extract of larrea tridentata and method of making the s

1998-09-11

1999-12-21

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A01N 6500

Patent

active

060045590

ABSTRACT:
A nontoxic, therapeutic agent having pharmacological activity comprising concentrated extract of Larrea tridentata plant material and ascorbic acid, an ascorbic acid ester, an ascorbic acid salt, butylated hydroxyanisole, butylated hydroxytoluene, hydrogen sulfide, hypophosphorous acid, monothioglycerol, potassium bisulfite, propyl gallate, sodium bisulfite, sodium hydrosulfite, sodium thiosulfate, sulfur dioxide, sulfurous acid, a tocopherol, or vitamin E is made by a process in which the plant material is extracted using an organic solvent, preferably acetone, and is then saturated with one of the listed reducing agents acid to reduce the toxic NDGA quinone, which naturally occurs in the plant material, to NDGA itself. Additional amounts of ascorbic acid, an ascorbic acid ester, an ascorbic acid salt, butylated hydroxyanisole, butylated hydroxytoluene, hydrogen sulfide, hypophosphorous acid, monothioglycerol, potassium bisulfite, propyl gallate, sodium bisulfite, sodium hydrosulfite, sodium thiosulfate, sulfur dioxide, sulfurous acid, a tocopherol, or vitamin E may be added to the extract to inhibit the natural oxidation of the NDGA into the toxic NDGA quinone in vivo, or during processing or storage. The resulting extract is useful in the treatment of viral diseases caused by viruses from the Herpesviridae family or viruses which require the Sp1 class of proteins to initiate viral replications. The resulting compound can also be used as an anti-inflammatory when the inflammatory diseases are mediated by the effects of leukotrienes. The listed reducing agents can also be used to stabilize NDGA as a therapeutic agent or a food additive.

REFERENCES:
patent: 2382475 (1945-08-01), Gisvold
patent: 4765927 (1988-08-01), Nomura et al.
patent: 4774229 (1988-09-01), Jordan
patent: 4880637 (1989-11-01), Jordan
patent: 5276060 (1994-01-01), Neiss et al.
Timmerman "Practical uses of Larrea," in "Creosote Bush: Biology and Chemistry of Larrea in the New World Deserts," Mabry et al. eds. (1977) (Dowden, Hutchison and Ross; Pennsylvania) pp. 252-276.
Gnabre et al., Isolation of anti-HIV-1 Lignans from Larrea tridentata, Tetrahedron (1995) 51(4):12203-12210.

Affiliated with

Also associated with

Rating

Nontoxic extract of larrea tridentata and method of making the s does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nontoxic extract of larrea tridentata and method of making the s, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nontoxic extract of larrea tridentata and method of making the s will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-502266