Nonthrombogenic articles and method of preparation

Details Nonthrombogenic articles and method of preparation Nonthrombogenic articles and method of preparation

1979-09-17

1981-11-24

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

3 1, 260 9, 424 83, C08L 510

Patent

active

043023681

ABSTRACT:
The disclosure is of articles having reduced thrombogenicity and which are useful for purposes requiring their contact with whole blood. The articles comprise solid, polymeric resin substrates to which there is fixed a compound of the formula: ##STR1## wherein R is alkyl of 12 to 18 carbon atoms, inclusive, R.sub.1 is lower alkyl and A is the negative ion of a soluble salt of heparin. The articles advantageously exhibit low toxicity and excellent blood compatibility when used for purposes which bring them into contact with whole blood for prolonged periods of time.

REFERENCES:
patent: 3457098 (1969-07-01), Leininger
patent: 3514438 (1970-05-01), Bixler
patent: 3616935 (1971-11-01), Love
patent: 3617344 (1971-11-01), Leininger
patent: 3634123 (1972-01-01), Eriksson
patent: 3755218 (1973-08-01), Yen
patent: 3810781 (1974-05-01), Eriksson
patent: 3844989 (1974-10-01), Harumiya
patent: 3846353 (1974-11-01), Grotta
patent: 4118485 (1978-10-01), Eriksson

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