Nonthrombogenic articles and method of preparation

Details Nonthrombogenic articles and method of preparation Nonthrombogenic articles and method of preparation

1979-09-17

1982-09-14

Michl, Paul R.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

424 78, 424 83, 523112, A61K 3175

Patent

active

043494676

ABSTRACT:
The disclosure is of articles having reduced thrombogenicity and which are useful for purposes requiring their contact with whole blood. The articles comprise solid, polymeric resin substrates to which there is fixed a compound of the formula: ##STR1## wherein R.sub.1 is alkyl of 12 to 18 carbon atoms, inclusive; R.sub.2, R.sub.3 and R.sub.4 are each independently selected from the group consisting of hydrogen and lower alkyl; X represents a negative monovalent ion such as halogen; and A represents the residue of a salt of heparin after removal of the positive ion. The articles advantageously exhibit low toxicity and excellent blood compatibility when used for purposes which bring them into contact with whole blood for prolonged periods of time.

REFERENCES:
patent: 3457098 (1969-07-01), Leininger
patent: 3514438 (1970-05-01), Bixler
patent: 3616935 (1971-11-01), Love
patent: 3617344 (1971-11-01), Leininger
patent: 3634123 (1972-01-01), Eriksson
patent: 3755218 (1973-08-01), Yen
patent: 3810781 (1974-05-01), Eriksson
patent: 3844989 (1974-10-01), Harumiya
patent: 3846353 (1974-11-01), Grotta
patent: 4118485 (1978-10-01), Eriksson

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