Nonthrombogenic articles and method of preparation

Details Nonthrombogenic articles and method of preparation Nonthrombogenic articles and method of preparation

1980-12-03

1983-01-11

Howell, Kyle L.

Surgery

Truss

Pad

128DIG22, 128638, 604 53, A61B 1900

Patent

active

043677495

ABSTRACT:
The disclosure is of articles having reduced thrombogenicity and which are useful for purposes requiring their contact with whole blood. The articles comprise solid, polymeric resin substrates to which there is fixed a compound of the formula: ##STR1## wherein R is alkyl of 12 to 18 carbon atoms, inclusive, R.sub.1 is lower alkyl and A is the negative ion of a soluble salt of heparin. The articles advantageously exhibit low toxicity and excellent blood compatibility when used for purposes which bring them into contact with whole blood for prolonged periods of time.

REFERENCES:
patent: 3550581 (1970-12-01), Boyle
patent: 3759788 (1973-09-01), Gajewski

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