Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1982-05-03
1984-02-28
Raymond, Richard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
42424852, 42424855, 42424857, 424250, 424263, 424266, 424267, 544141, 544372, 546208, 546281, 548517, 548518, 548539, A61K 31405, C07D20736
Patent
active
044341750
ABSTRACT:
5-Aroyl-4-RO-, 5-aroyl-4-RS-, 5-aroyl-4-RSO-, 5-aroyl-4-RSO.sub.2 -, or 5-pyrrylcarbonyl-pyrrole alkanoic acid have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation or from direct acidic decarboxylation of a precursor diacid. The compounds are analgesic and anti-inflammatory agents of high activities but low ulcerogenic side effects.
REFERENCES:
patent: 3952012 (1976-04-01), Carson
patent: 4048191 (1977-09-01), Carson
patent: 4087539 (1978-05-01), Muchowski
patent: 4097579 (1978-06-01), Muchowski
patent: 4119639 (1978-10-01), Carson
patent: 4232038 (1980-11-01), Muchowski
Carson & Wong, J. Med. Chem., 16(2), 172 (1973).
Chang Michael N.
Doherty James B.
Dorn Conrad P.
Cheng Theresa Y.
Merck & Co. , Inc.
Monaco Mario A.
Raymond Richard
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