Nonpeptidyl integrin inhibitors having specificity for the GPII.

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514220, 514221, 540493, 540495, 540504, 540512, A61K 3155

Patent

active

055654495

ABSTRACT:
A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.

REFERENCES:
patent: 5403836 (1995-04-01), Blackburn et al.

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