Nonpeptides as tachykinin antagonists

Details Nonpeptides as tachykinin antagonists Nonpeptides as tachykinin antagonists

1995-03-20

1996-09-10

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514396, 514399, 5142312, 5142375, 5142378, 5142388, 514255, 514408, 514419, 514430, 514443, 514469, 514513, 514595, 544106, 544162, 544170, 544171, 544358, 544382, 544398, 544399, 544400, 544402, 546329, 546339, 546340, 546341, 546342, 5483001, 5483351, 5483355, 5483381, 5483401, 5483411, 5483415, 549 29, 549 78, 549 79, 549 49, 549 58, 549496, 560 19, 560 43, 560 55, 560 61, 560103, 560106, 564 47, A61K 3140, C07D20910

Patent

active

055546412

ABSTRACT:
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK.sub.3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.

REFERENCES:
patent: 5348976 (1994-09-01), Shibata et al.
CA 109:6970g Preparation . . . agents. Horwell et al., p. 606, 1988.
P. Boden, et al. Bioorg & Med Chem Lett, 1994, 4:14, 1679-1684.
X. Edmonds-Alt, et al., Life Sci, 1995, 56:PL 27-32.

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