Nonpeptide insulin receptor agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514150, 514477, 514483, 514562, 514563, 514596, 514597, 514598, 514617, 514618, 514619, 514708, 514762, 514866, A61K 3105, A61K 3110, A61K 3117, A61K 31655

Patent

active

058519882

ABSTRACT:
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## wherein

REFERENCES:
Brinkworth, R.I. et al. "Non-Peptidic Anti-AIDS Agents: Inhibition of HIV-1 proteinase by Disulfonates," Biochemical and Biophysical Research Communities (1992) 188(2):624-630.
Kirchberger, J. et al. "Studies of the interaction of NADH oxidase from Thermus thermophilis HB8 with triazine dyes," Journal of Chromatography A (1994) 668:153-164.
Kletzien, R.F. et al. "Enhancement of Adipocyte Differentiation by an Insulin-Sensitizing Agent," Molecular Pharmacology (1991) 41:393-398.
Kobayashi, M. et al. "Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase," Diabetes (1992) 41:476-483.

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