Nonpeptide insulin receptor agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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A61K 31135

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active

058309187

ABSTRACT:
Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## wherein each Ar is independently an aromatic moiety; each A is independently a proton-accepting substituent;

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Kletzien, R. F., et al., "Enhancement of Adipocyte Differentiation by an Insulin-Sensitizing Agent" J. Mol Pharmacol (1992) 41:393-398.
Kobayashi, M. Pioglitazone Increases Insulin Sensitivity by Activating Insulin Receptor Kinase Diabetes (1992) 41:476-483.

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