Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-01-22
2000-01-25
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514314, 514336, 514338, 514397, 514414, 514444, 514452, 514464, 514465, 514466, 514469, 514473, A61K 31535, A61K 3138, A61K 31335
Patent
active
060179163
ABSTRACT:
Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.
REFERENCES:
patent: 4594443 (1986-06-01), Bianchi et al.
patent: 4968817 (1990-11-01), Brima
PCT International Search Report, PCT/US94/09091.
Foley et al., Neurosurgery, 1994, 34:1, 108-113.
Rio and Hardy, Bulletin de la Societe Chimique de France, 1970, 10, 3572-3578.
Patwardham and Bagawant, Indian Journal of Chemistry, 1973, 11:9, 1333-1334.
McEvoy and Allen, J. Med. Chem., 1974, 17:3, 281-286.
Dikshit et al., Indian Journal of Chemistry, 1990, 29B, 954-960.
Krapf et al., Chem. Ber., 1976, 109, 576-596.
Schmand et al., Liebigs. Ann. Chem., 1976, 1560-1576.
Rohrscheidt and Fritz, Liebigs. Ann. Chem., 1878, 680-693.
Padwa et al., J. Am. Chem. Soc., 1978, 100:26, 8247-8259.
Chelain et al., J. Am. Chem. Soc., 1992, 114, 8088-8098.
Weinberg and Miller, J. Org. Chem., 1979, 44:25, 4722-4725.
Canevet and Graff, Tetrahedron, 1978, 34, 1935-1942.
Mise et al., J. Org. Chem., 1983, 48, 238-242.
Anselmi et al., J. Heterocyclic Chem., 1983, 20, 687-689.
Yoshida et al., Bull. Chem. Soc. Jpn., 1983, 56, 3849-3850.
Daroca et al., Monatschefte fur Chemis, 1984, 115, 357-373.
Falsone and Vingen, Arch. Pharm., 1984, 317, 802-806.
Verma et al., Synthesis, 1988, 1, 68-70.
Pratapan et al., J. Org. Chem., 1988, 53, 5826-5831.
Kraft and Pankowski, Tetrahedron Letters, 1990, 31:36, 5139-5142.
Alcaide and Rodriguez-Lopez, J. Chem. Soc.-Perkin Trans., 1990, 1, 2451-2457.
Dinumlescu et al., Journal of Organometallic Chemistry, 1977, 140, 91-96.
Chan et al., Journal of Organometallic Chemistry, 1987, 334, 9-56.
Pennanen, Heterocycles, 1977, 6:6, 701-706.
Endo and Shudoa, Heterocycles, 1992, 33:1, 91-95.
Dotz et al., Journal of Organometallic Chemistry, 1993, 459, 169-176.
Herndon and Zora, Synlett, 1993, 5, 363-364.
Tyvorskii and Kukharev, Russian Journal of Organic Chemistry, 1993, 29:5(2), 840-843.
Clozel et al., Nature, 1993, 365, 759-761.
Watababe, Nature, 1990, 344, 114.
Marguiles et al., Circulation, 1990, 82:6, 2226-
Kon et al., J. Clin. Invest., 1989, 83, 1762-1767.
Perico et al., J. Am. Soc. Nephrol., 1990, 1:1, 76-83.
Koshi et al., Chem. Pharm. Bull, 1991, 39:5, 1295-1297.
Miyamori et al., Clin. Exp. Pharmacol. Physiol., 1990, 17, 691-696.
Ohno, J. Toyko Women's Medical College, 1991, 61:10-11, 951-959.
Lerman et al., Circulation, 1991, 83:5, 1808-1814.
Rodeheffer et al., Am. J. Hypertension, 1991, 4:9A-10A.
Arai et al., Nature, 1990, 348, 730-732.
Sakurai et al., Nature, 1990, 348, 732-735.
Lin et al., Proc. Natl. Acad. Sci. USA, 1991, 88, 3185-3189.
Sakamoto et al., Biochem. Biophys. Res. Chem., 1991, 178:2, 656-663.
Hosoda et al., FEBS Lett., 1991, 287:1,2; 23-26.
Takayanagi et al., FEBS Lett., 1991, 282:1, 103-106.
Sakamoto et al., Biochem. Biophys. Res. Chem., 1991, 178:2, 656-663.
Panek et al., Biochem. Biophys. Res. Chem., 1992, 183:2, 566-571.
Sacki et al., Biochem. Biophys. Res. Chem., 1991, 179:1, 286-292.
Nakagawa et al., Nippon Hifuka Gakkai Zashi, 1990, 100, 1453-1456.
Noguchi et al., Am. Rev. Respir. Dis., 1992, 145 (Part 2), A858.
Clark et al., Am. J. Obstet. Gynecol., 1992, 166:3, 962-968.
Pittet et al., Ann. Surg., 1991, 213:3, 261-264.
Gandhi et al., J. Biol. Chem., 1990, 265:29, 17432-17435.
Collier et al., Diabetes Care, 1992, 15:8, 1038-1040.
Nikolov and Semkova, Drugs of Today, 1992, 28:5, 303-310.
Lerman et al., New England J. Med., 1991, 325:14, 997-1001.
Kanao et al., J. Amer. Med. Assoc., 1990, 264:22, 2868.
Zamora et al., Lancet, 1990, 336, 1144-1147.
Tahara et al., Metabolism, 1991, 40:12, 1235-1237.
Stewart et al., Annals of Internal Medicine, 1991, 114:6, 464-469.
Yasuda et al., American Heart Journal, 1990, 119:4, 801806.
Stewart et al., Br. Heart J., 1991, 66, 7-9.
Lopez-Farre et al., Journal of Physiology, 1991, 444, 513-522.
Stockenhuber et al., Clinical Science, 1992, 82, 252-258.
Miura et al., Digestion, 1991, 48, 163-172.
Masuda et al., Am. J. Physiol., 1992, 262, G785-G790.
Murch et al., Lancet, 1992, 339, 381-384.
Clozel and Watanabe, Life Sciences, 1993, 52:9, 825-834.
Basil et al., J. Hypertension, 1992, 10(Suppl. 4), S49.
Han et al., Life Sciences, 1990, 46:11, 767-775.
Allen et al., Can. J. Chem., 1956, 34, 926-930.
Allen and Frame, Can. J. Research, 1932, 6, 605-613.
Allen et al., Can. J. Research, 1934, 11, 382-394.
Allen et al., Can. J. Research, 1933, 8, 137-141.
Rovero et al., Br. J. Pharmacol., 1990, 101, 232-234.
Clozel et al., Third Intl. Conf. on Endothelin, Abstract Book, Feb. 5-17, 1993, p. 17.
Doherty et al., Bioorg. & Med. Chem. Lett., 1990, 3:4, 497-502.
Stein et al., J. Med. Chem., 1994, 37:3, 329-331.
Berryman Kent Alan
Doherty Annette Marian
Edmunds Jeremy John
Patt William Chester
Plummer Mark Stephen
Anderson Elizabeth M.
Owens Amelia
Warner-Lambert & Company
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