Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-02-06
1997-11-25
Owens, Amelia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142338, 514314, 514336, 514338, 514414, 514397, 514444, 514452, 514464, 514465, 514466, 514469, 514473, 549 60, 549318, 549313, 549321, 549438, 5483117, 548454, 548466, 546152, 5462837, 5462844, 544153, A61K 3136, A61K 3138, A61K 3144, A61K 31535
Patent
active
056913737
ABSTRACT:
Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.
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Berryman Kent Alan
Doherty Annette Marian
Edmunds Jeremy John
Patt William Chester
Plummer Mark Stephen
Anderson Elizabeth M.
Owens Amelia
Warner-Lambert & Company
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