Nonpathogenic infectious bursal disease virus and vaccine

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

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4241301, 4241391, 4241411, 4241471, 4241591, 5303883, 435236, 435237, 435238, 435239, A61K 3912, C12N 704, C12N 706, C12N 708

Patent

active

059194618

ABSTRACT:
An Infectious Bursal Disease Virus of the Delaware Variant E type having the characteristics of being able to grow on both VERO cells and CEF cells, reacting with monoclonal antibody BK9 produced by the cell line having ATCC deposit number HB-10157, not causing bursal atrophy after vaccination and not spreading to birds in physical proximity to immunized birds, said virus being identified as Delaware Variant E 89-03.

REFERENCES:
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patent: 5192539 (1993-03-01), Van De Marel et al.
patent: 5518724 (1996-05-01), Snyder et al.
Kibenge et al. "Biochemistry and Immunology of Infectious Bursal Disease Virus". Journal of General Virology. vol. 69:1757-1775, 1988.
Snyder, D.B. et al., "Differentiation of Infectious Bursal Disease Viruses Directly from Infected Tissues with Neutralizing Monoclonal Antibodies: Evidence of a Major Antigenic Shift in Recent Field", Avian Diseases 32, 535-539, 1988.
Mohanty, S.B., Veterinary Virology, Lea & Febiger, Philadelphia, p. 91 (1981).
Rosenberger, J.K. et al., "Isolation & Characterization of Variant Infectious Bursal Disease Virus", Abstract 123 Am. Vet. Med. Assoc. Meeting, p. 357 (1986).
Lutticken, D.R.W. et al.; "Cross Protection Studies in Chickens Involving Different Bursal Disease Subtypes", Amsterdam, pp. 456-459, Sep., 1992.
Rosenberger, J.K. et al., "Update on Delmarva Respiratory Complex and Use of Variant IBDV Vaccines", Proceedings 1986 Poultry Health Condemnation Meeting, Ocean City MD.
Rosenberger, J.K. et al., "Sentinel Bird Survey of Delmarva Broiler Flocks", 1985.
Rosenberger, J.K. et al., "1987 Sentinel Bird Study of Delmarva Poultry", Proceedings Poultry Health and Condemnation Meeting, 1987.
Snyder, D.B. et al., "Rapid Serological Profiling by Enzyme-Linked Immunosorbent Assay", Avian Diseases, vol. 30, No. 1, pp. 139-148 (1985).

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