Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lipoproteins – e.g. – egg yolk proteins – cylomicrons – etc.
Patent
1992-10-08
1995-04-18
Parr, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lipoproteins, e.g., egg yolk proteins, cylomicrons, etc.
536 235, 435 71, C07K 1516, C07H 2104, G01N 3353
Patent
active
054080380
ABSTRACT:
Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
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Hopp/Wood, Proc. Natl. Acad. Sci. USA, 78:3824 (1981).
Hopp, T. P. Review article: Protein surface analysis, Methods for identifying antigenic determinants and other interaction sites. J. Immunol. Methods (1986) 8:1-18.
Karathanasis, S. K. et al. Isolation and characterization of the human apolipoprotein A-I gene, Proc. Natl. Acad. Sci. USA (1983) 80:6147-6151.
Cladaras, C. et al, The complete sequence and structural analysis of human apolipoprotein B-100: relationship between apoB-100 and apoB-48 forms. EMBOJ. (1986) 5:3495-3507.
Curtiss Linda K.
Koduri Kanaka R.
Smith Richard S.
Witztum Joseph L.
Young Stephen G.
Parr Margaret
Schreiber David
The Scripps Research Institute
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