Nonirritating emulsions for sensitive tissue

Details Nonirritating emulsions for sensitive tissue Nonirritating emulsions for sensitive tissue

1994-05-17

1995-12-12

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514785, 514786, 514912, 514941, 514943, 514975, A61K 3813, A61K 4734

Patent

active

054749794

ABSTRACT:
A pharmaceutical composition is disclosed in the form of a nonirritating emulsion which includes at least one cyclosporin in admixture with a higher fatty acid glyceride and polysorbate 80. More particularly, the cyclosporin may be cyclosporin A and the higher fatty acid glyceride may be castor oil. Composition has been found to be of a high comfort level and low irritation potential suitable for delivery of medications to sensitive areas such as ocular tissues. In addition, the composition has stability for up to nine months without crystallization of cyclosporin.

REFERENCES:
patent: 4347238 (1982-08-01), Hollingsbee
patent: 4839342 (1989-06-01), Kaswan
patent: 4990337 (1991-02-01), Kurihara et al.
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5051402 (1991-09-01), Kurihara et al.
patent: 5364632 (1994-11-01), Benita et al.

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