Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-10-28
1999-02-09
Dentz, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549410, 549412, 526328, C07D31172, C08F 2020
Patent
active
058697039
ABSTRACT:
Disclosed herein are nonionic vitamin E or polyethoxylated vitamin E derivatives represented by the following formula (I) and a method for the preparation thereof, and polymeric amphiphilic vesicles made therefrom. ##STR1## wherein, n is an integer from 0 to 30, inclusive;
A is --CH.sub.2 --CH(CH.sub.3)-- or --CH.dbd.C(CH.sub.3)--;
B is --CH.sub.3 at the 5-, 7- or 8- position;
m is 1, 2, or 3; and
R is residue of acrylate or methacrylate derivatives represented by the following formula (II); ##STR2## wherein, R.sub.1 is H or CH.sub.3.
REFERENCES:
Hargreaves et al., "Liposomes from Ionic, Single-Chain Amphiphiles" Monoalkyl Liposomes pp. 3759-3760 (1978).
Ohno et al., "Polymerization of Diene-Containing Lipids as Liposomes by Radical Initiators. 4..sup.1 Effect of Lipid Packing on the Polymerization Profile" Macromolecules pp. 319 (1988).
Takeoka et al., "Polymerization of Liposomes Evaluated from Molecular Weight Distribution of Diene-Type Phospholipid Polymers" Polymer Journal 22:867-874 (1990).
Chemical Abstract 127:230924-Abst. of Cho et al, Macromol. Symp., 118, pp.631-640 (1997).
Cho Iw Han
Kim Min Ki
Kim Won Chae
Kim Young Dae
Kim Young Hyun
Dentz Bernard
Pacific Corporation
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