Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-06-05
1997-03-25
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548544, 548545, 548547, 548551, C07D20702
Patent
active
056146388
ABSTRACT:
New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, ##STR2## --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-- or ##STR3## R.sub.1, R.sub.1 ' and R.sub.2 are the same or different and are hydrogen, alkyl or hydroxyalkyl.
Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups. Preferred hydroxyalkyl groups include: ##STR4## R.sub.3 and R.sub.4 are the same or different and are hydrogen, methyl or --CH.sub.2 CH.sub.2 OH; R.sub.5 is hydrogen, alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH or OH and R.sub.6 is alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH, OH or hydrogen and may be the same or different than R.sub.5 and m is zero or one, with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond, m is not zero.
These new contrast agents are water soluble and have desirable low osmolality and anticoagulant properties.
REFERENCES:
patent: 2750393 (1956-06-01), Elpern
patent: 2776241 (1957-01-01), Priewe et al.
patent: 3306927 (1967-02-01), Larsen
patent: 3701771 (1972-10-01), Almen et al.
patent: 3883535 (1975-05-01), Felder et al.
patent: 3890318 (1975-06-01), Obendorf et al.
patent: 3925412 (1975-12-01), Obendorf et al.
patent: 4001298 (1977-01-01), Gries et al.
patent: 4001323 (1977-01-01), Felder et al.
patent: 4066743 (1978-01-01), Kneller
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4352788 (1982-10-01), Felder et al.
patent: 4845235 (1989-07-01), Matumoto et al.
patent: 4962204 (1990-10-01), Wambach
Fumagalli, et al., "Radiopaque Contrast Media", Pharmazie, 30, H.2, pp. 78-79. (1980).
Stormorken et al., "Effect of Various Contrast Media on Coagulation, Fibrinolysis, and Platelet Function: An In Vitro and In Vivo Study", Investigative Radiology, vol. 21, Apr. 1986, pp. 348-354.
Mamon et al., "Biochemical Evidence for a Relative Lack of Inhibition of Thrombin Formation by Nonionic Contrast Media", Radiology 1991; 179:399-401.
G. B. Hoey et al., "Chemistry of X-Ray Contrast Media" pp. 23-125. (1989).
Laerum et al., "Postphlebographic Thrombosis", Diagnostic Radiology, Sep. 1981, pp. 651-654.
Arunchalam Thangavel
Marinelli Edmund R.
Pillai Radhakrishna K.
Ranganathan Ramachandran S.
Bracco International B.V.
Hoare George P.
Peabody John
Rhoads Donald L.
Richter Johann
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