Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1993-10-27
1997-01-07
Shippen, Michael L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540202, 540356, 540451, 540492, 540526, 540531, 544 97, 544169, 544316, 544384, 544385, 546220, 546221, 546243, 548229, 5483241, 548550, C07D20508
Patent
active
055918468
ABSTRACT:
New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, ##STR2## R.sub.1, R.sub.1 ' and R.sub.2 are the same or different and are hydrogen, alkyl or hydroxyalkyl.
Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups. Preferred hydroxyalkyl groups include: ##STR3## R.sub.3 and R.sub.4 are the same or different and are hydrogen, methyl or --CH.sub.2 CH.sub.2 OH; R.sub.5 is hydrogen, alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH or OH and R.sub.6 is alkyl, --CH.sub.2 CH.sub.2 OH, CH.sub.2 OH, OH or hydrogen and may be the same or different than R.sub.5 and m is zero or one, with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond, m is not zero. These new contrast agents are water soluble and have desirable low osmolality and anticoagulant properties.
REFERENCES:
patent: 2750393 (1956-06-01), Elpern
patent: 2776241 (1957-01-01), Priewe et al.
patent: 3306927 (1967-02-01), Larsen
patent: 3701771 (1972-10-01), Almen et al.
patent: 3883535 (1975-05-01), Felder et al.
patent: 3890318 (1975-06-01), Obendorf et al.
patent: 3925412 (1975-12-01), Obendorf et al.
patent: 4001298 (1977-01-01), Gries et al.
patent: 4001323 (1977-01-01), Felder et al.
patent: 4066743 (1978-01-01), Kneller
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4352788 (1982-10-01), Felder et al.
patent: 4845235 (1989-07-01), Matumoto et al.
patent: 4962204 (1990-10-01), Wambach
patent: 5075502 (1991-12-01), Kneller et al.
patent: 5191120 (1993-03-01), Kneller et al.
patent: 5278311 (1994-01-01), Arunachalom et al.
Fumagalli, et al., "Radiopaque Contrast Media", Pharmazie, 30, H.2, pp. 78-79. (1974).
Stormorken et al., "Effect of Various Contrast Media on Coagulation, Fibrinolysis, and Platelet Function: An In Vitro and In Vivo Study", Investigative Radiology, vol. 21, Apr. 1986, pp. 348-354.
Mamon et al., "Biochemical Evidence for a Relative Lack of Inhibition of Thrombin Formation by Nonionic Contrast Media", Radiology 1991; 179:399-401.
Laerum et al., "Postphlebographic Thrombosis", Diagnostic Radiology, Sep. 1981, pp. 651-654.
Arunchalam Thangavel
Marinelli Edmund R.
Pillai Radhakrishna K.
Ranganathan Ramachandran S.
Bracco International B.V.
Hoare George P.
Rhoads Donald L.
Shippen Michael L.
LandOfFree
Nonionic radiographic contrast agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nonionic radiographic contrast agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nonionic radiographic contrast agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1765314