Noninvasive detection of rejection in heart transplant patients

Surgery – Truss – Pad

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61B 50452

Patent

active

052857930

ABSTRACT:
A method and apparatus for diagnosing heart rejection is disclosed. Heart rejection is diagnosed based on the pattern of interbeat intervals. The interbeat intervals of the heart are measured shortly after transplant to establish a baseline pattern. The patterns of interbeat intervals from subsequent measurements are compared to the baseline to detect changes from the baseline indicating rejection. The apparatus of the invention measures the interbeat intervals using a Schmidt trigger that detects the upstroke of the QRS and produces a corresponding pulse. The intervals between pulses are timed to produce a series of interbeat interval measurements that are stored and analyzed. Software provides for automated pattern analysis.

REFERENCES:
patent: 4583553 (1986-04-01), Shah et al.
patent: 4905707 (1990-03-01), Davies et al.
patent: 4911170 (1990-03-01), Thomas, III et al.
patent: 5058597 (1991-10-01), Onoda et al.
patent: 5139028 (1992-08-01), Steinhaus et al.
"Automatic Extractions of Sinusoidal RR-Intervals from ECG-Signals, " by B. M. Tsukerman, et al., A. V. Vishnevskii Surgical Institute of Acadamy of Medical Sciences, Moscow, translated from Meditsinskaya Tekhnika, No. 6, pp. 18-21, Nov.-Dec., 1984.
"Technical Note: An Interval Timer with Computer Interface" by R. McGillivray, et al., Journal of Clinical Engineering, vol. 12, No. 6, Nov.-Dec. 1987.
"Computer Analysis of the Electrocardiogram During Esophageal Pacing Cardiac Stress" by Hossein Jadvar, et al, IEEE Transactions on Biomedical Engineering, vol. 38, No. 11, Nov., 1991.
"Analogue preprocessor for the measurement by a digital computer of R-R intervals and R wave widths" by A. Sandman, et al., pp. 191-200, Medical and Biological Engineering, Mar., 1973.
"Improved ECG R-R Interval Measurement" by A. A. Smerdov et al., All Union Medical Electronics Research and Design Institute, L'vov. Translated from Meditsinskaya Tekhnika, No. 2, pp. 22-24, Mar.-Apr., 1979.
"An Algorithm for Microprocessor-Based QRS Detection" by Omar Escalona, et al. Journal of Clinical Engineering, vol. 11, No. 3, May-Jun. 1986.
"Beat-to-Beat Interval Measurement in the Electrocardiogram," by A. S. M. Koeleman, et al., Medical and Biological Engineering and Computing, No. 23, pp. 213-219, May, 1985.
"ECG Variation with R-R Interval and with Time-Since-Breath in Quiet Subjects" by J. E. Goodfellow, pp. 93-94, 1990 IEEE.
"A 24-Hour ECG Monitoring System for Ambulatory Patient," by M. Grulli, et al, pp. 577-580, 1988 IEEE.
"A Simple Processing of R-R Interval Time Sequences to Detect Atrial Fibrillation Subtypes in Ambulatory Patients" G. P. Duca, et al., pp. 255-258.
"Precision Digital Instrument for Calculation of Heart Rate and R-R Interval" by Kenneth D. Taylor, et al., pp. 255-257, IEEE Transactions on Biomedical Engineering, May, 1975.
Anan, T., Sunagawa, K., Araki, H., and Nakamura, M., "Arrhythmia Analysis by Successive RR Plotting," Journal of Electrocardiology, 23(3):243-48 (Jul. (1990).
Babloyantz, A., "Some Remarks on Nonlinear Data Analysis of Physiological Time Series." In Abraham, N. B. (ed): Measures of Complexity of Chaos, Plenum Press, New York (1989).
Barbaro, V., Bartolini, P., and Fierli, M., "New Algorithm for the Detection of the ECG Fiducial Point in the Averaging Technique," Medical & Biological Engineering & Computing, 29:129-35 (Mar. 1991).
Boone, R., Gross, G. W., and Greco-Hunt, V., "Neutral Networks in Radiologic Diagnosis: I. Introduction and Illustration," Investigative Radiology, 25:1012-16 (Sep. 1990).
Brown, R., Bryant, P., and Abarbanel, H. D. I., "Computing the Lyapunov Spectrum of a Dynamical System From an Observed Time Series," Physical Review A, 43:2787-2806 (1991) (pp. 2789-2791 enclosed).
Bugarin, A., Barro, S., Ruiz, R., Presedo, J., and Palacios, F., "Syntactic Characterization of QRS Morphology," Annual Int'l. Conf. of the IEEE Eng. in Medicine & Biology Society, 13(2):588-89 (1991).
Butler, L. A., "Robust Real-Time R-Wave Detection for Microprocessors," Annual Int'l. Conf. of the IEEE Eng. in Medicine & Biology Society, 13(2):594-95 (1991).
Cahill, S. J., and McClure, G., "A Microcomputer-Based Heart-Rate Variability Monitor," IEEE Trans. Biomedical Engineering, 30(2):87-92 (Feb. 1983).
Casolo, G., Balli, E., Taddei, T., Amuhasi, Jr. and Gori, C., "Decreased Spontaneous Heart Rate Variability in Congestive Heart Failure," The American Journal of Cardiology, 64:1162-67 (Nov. 1989).
Chan, K. H., and Lin, J. C., "Microprocessor-Based Cardiopulmonary Rate Monitor," Medical & Biological Engineering & Computing, 25:41-44 (Jan. 1987).
Chialvo, D. R., Gilmour, Jr., R. G., and Jalife, J., "Los Dimensional Chaos in Cardiac Tissue," Nature 343:653-57 (Feb. 1990).
CIO-AD16Jr. I/O Board Product Literature, Computer Boards, Inc., Mansfield, Mass., pp. 1-3.
CIO-CTR05 16 Bit Counter/Timer Board Product Literature, Computer Boards, Inc., Mansfield, Mass., p. 27.
Eckman, J. P., Kamphorst, S. I., Ruelle, D., "Recurrence Plots of Dynamical Systems." Europhys. Lett., 4(9):973-977 (1987).
Ewing, D. J., Neilson, J. M. M., and Travis, P., "Irregularities of R-R Interval Cycle Length During 24 Hour ECG Tape Recording," Scottish Medical Journal, 29:30-31 (1984).
Farmer, J. D., "Information Dimension and the Probabilistic Structure of Chaos." Z. Naturforsch, 37a, 1304-1325 (1982).
Farmer, J. D., Ott, E., Yorke, J. A., "The Dimension of Chaotic Attractors." Physica., 7D, 153-180 (1983).
Fraser, A. M., "Information and Entrophy in Strange Attractors," IEEE Trans. Information Theory, 35(2):245-62 (Mar. 1989).
Fraser, A. M., and Swinney, H. L., "Independent Coordinates for Strange Attractors from Mutual Information," Physical Review A, 33(2):1134-40 (Feb. 1986).
Glass, L., and Mackey, Mc, From Clocks to Chaos the Rythms of Life, Princeton University Press, Princeton, N.J., pp. 42-48 (1988).
Gleick, J., Chaos: Making a New Science, Penjuin, pp. 262-267 (1987).
Goldberger, A. L., Rigney, D. R., and West, B. J., "Chaose and Fractuals in Human Physiology," Scientific American, pp. 43-49 (Feb. 1990).
Goldberger, A. L., and West, B. J., "Applicatoins of Nonlinear Dynamics to Clinical Cardiology," Annals New York Academy of Sciences, 504 ( ):195-213 (1987).
Grace, A. A., Newell, S. A., Cary, N. R. B., Scott, J. P., Large, S. R., Wallwork, J., and Schofield, P. M., "Diagnosis of Early Cardiac Transplant Rejection by Fall in Evoked T Wave Amplitude Measured Using an Externalized QT Driven Rate Responsive Pacemaker." PACE 14:1024-1031 (1991).
Gregson, P. H., and McKay, W. P. S., "A Robust QRS-Complex Detector Using an Equivalence Class Characteristics," Annual Int'l. CXonf. of IEEE Eng. in Medicine & Biology Society, 13(2):596-97 (1991).
Gulick, Denny, Encounters with Chaos, McGraw Hill, Inc. (1992).
Gustafson, D. E., Willsky, A. S., Wang, J., Lancaster, M. C., and Triebwasser, J. H., "ECG/VCG Rhythm Diagnosis Using Statistical Signal Analysis--I. Identification of Persistent Rhythms," IEEE Trans. Biomedical Engineering, 25(4):344-52 (Jul. 1978).
Gustafson, D. E., Willsky, A. S., Wang, J., Lancaster, M. C., and Triebwasser, J. H., "ECG/VCG Rhythm Diagnosis Using Statistical Signal Analysis-II. Identification of Transient Rhythms," IEEE Trans. Biomedical Engineering, 25(4):353-61 (Jul. 1978).
Haberl, R., Weber, M., Kemkes, B. M.,and Steinbeck, G., "Fourier Transformation of Electrocardiogram for Noninvasive Recognition of Acute Rejection after Orthotopic Heart Transplantation in Man." Biblthca Cardiol., 43:128-132 (Karger, Basel 1988).
Haberl, R., Weber, M., Reihenspurner, M., et al., "Frequency Analysis of the Surface Electrocardiogram for Recognition of Acute Rejection after Orthotopic Cardiac Transplantation in Man." Circulation, 76:101-108 (1987).
Heinz, G., Laufer, G., Ohner, T., Gasic, S., and Laczkovics, A., "Analysis of Heart Rate Changes in Cardiac Transplant Recipients Relates to Graft Rejection," The American Journal of Cardiology, 66:647-48 (Sep. 1990).
Hwang, S., Nam, S., Lee. J., and Lee, M., "A QRS Pattern Analysis Algorithm by Improved Significant Point Extraction Method," Annual Int'l. Conf. of the IEE Eng. in Medicine & Biol

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Noninvasive detection of rejection in heart transplant patients does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Noninvasive detection of rejection in heart transplant patients, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Noninvasive detection of rejection in heart transplant patients will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1200596

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.