Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2007-12-18
2007-12-18
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S018000, C800S009000
Reexamination Certificate
active
10533700
ABSTRACT:
The present invention intends to provide a non-human animal model of Guillain-Barré syndrome, which can be obtained by immunizing FcγRIIB-gene-deficient non-human animal with ganglioside GQ1b, and a screening method of a therapeutic agent for Guillain-Barré syndrome using the non-human animal model. A mouse model of Guillain-Barré syndrome is generated by immunizing FcγRIIB-gene-deficient mice with gangliosides GM1, GM2, GD1a, and GQ1btogether with Freund's adjuvant every three weeks four times in total.
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Nakamura Akira
Sugahara Akiko
Takai Toshiyuki
Yajima Kaori
Falk Anne-Marie
Japan Science and Technology Agency
Morgan & Finnegan L.L.P.
Singh Anoop K
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