Nonhomogeneous centrifugal film bioreactor

Details Nonhomogeneous centrifugal film bioreactor Nonhomogeneous centrifugal film bioreactor

1991-07-08

1993-09-28

Warden, Robert J.

Chemistry: molecular biology and microbiology

Miscellaneous

210219, 261 83, 261 84, 261 89, 422224, 422225, 422227, 422228, 435313, 435316, C12M 106

Patent

active

052486133

ABSTRACT:
A centrifugal film bioreactor useful for processing both shear sensitive and shear requiring or tolerant cells. A liquid phase is directed upward in a guide tube to rotating truncated conical surfaces which transport the liquid phase across their surfaces. After leaving the conical surfaces, the liquid passes through a gaseous phase and may contact the wall of the fermentation vessel and then combine with the downward moving liquid phase in the lower part of the fermentation vessel, where it circulates. The maximum entrainment of the gaseous phase into the liquid phase occurs while the liquid phase is passing through the gaseous phase. Different configurations of guide tube propellers and fermentation vessel, allow for processing of different shear tolerant cells.

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