Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1989-06-30
1992-07-07
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530824, 424 852, 424 851, 435 6952, 930141, 935 49, 935 50, C07K 1300, A61K 3702
Patent
active
051284502
ABSTRACT:
The present invention provides a pharmaceutical compositions comprising as active ingredients certain truncated purified human IL-3(Pro.sup.8 Asp.sup.15 Asp.sup.70) analog proteins expressed by transformed yeast of the species Saccharomyces cerevisiae, which when administered to a primate do not result in detectable urticaria.
REFERENCES:
patent: 4877729 (1989-10-01), Clark et al.
Clark-Lewis, Science 231, 1986, pp. 134-138.
Dunbar et al., Science, 1989, p. 1493.
Growth Factors and their Receptors; Genetic Control and Rational Application, Alan R. Liss, 1989, pp. 229-238.
Ihle et al., "Regulation of T Cell Differentiation: in vitro induction of 20a-Hydroxysteroid Dehydrogenase in Splenic Lymphocyte from Athymic Mice by a Unique Lymphokine," J. Immunol. 126:2184 (1981).
Fung et al., "Molecular Cloning of cDNA for Murine Interleukin-3," Nature 307:233 (1984).
Yokota et al., "Isolation and Characterization of a Mouse cDNA Clone that Expresses Mast-Cell Growth-Factor Activity in Monkey Cells," Proc. Natl. Acad. Sci. 81:1070 (1984).
Yang et al., "Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3." Cell47:3 (1986).
Ihle and Weinstein, Adv. Immuno. 39:1 (1986).
Dorssers et al., "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3." Gene 55:115 (1987).
Kaushansky et al., "Role of carbohydrate in the function of human granulocyte-macrophage colony-stimulating factor," Biochemistry 26:4861 (1987).
Berman and Lasky, "Engineering glycoproteins for use as pharmaceuticals." Trends in Biotechnology 3:51 (1985).
Miyajima et al., "Expression of murine and human GM-CSFs in S. cerevisiae: Mutagenesis of the potential glycosylation sites." EMBO J. 5:1193-1197 (1986).
Lopez et al., "Recombinant Human Interleukin-3 Stimulation of Hematopoiesis in Humans: Loss of Responsiveness with Differentiation in the Neutrophilic Myeloid Series." Blood 72:1797 (1988).
Otsuka et al., "Isolation and Characterization of an Expressible cDNA Encoding Human IL-3." J. Immunol. 140:2288 (1988).
Gillis et al., "Production of Recombinant Human Colony Stimulating Factors in Yeast" Behring Inst. Mitt. 83:1 (1988).
Urdal et al., "Molecular Characterization of Colony-Stimulating Factors and Their Receptors: Human Interleukin-3." Ann. N.Y. Acad. Sci 554:167 (1989).
Cosman et al., "Human Interleukin-3 and Granulocyte-Macrophage Colony Stimulating Factor: Site-Specific Mutagenesis and Expression in Yeast." Develop. biol. Standard. 69:9 (1988).
Zoller et al., "Oligonucleotide-directed mutagenesis using M 13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA." Nucl. Acids Res. 10: 6487-6500 (1982).
Wells et al., "Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites." Gene 34:315-323 (1985).
Kurzrock et al. "Phase I Study of Recombinant Human Interleukin-3 in Patients with Bone Marrow Failure." Blood 74(7):154a (1989).
Ganser et al. "Effects of Recombinant Human Interleukin-3 in Patients with Myelodysplastic Syndromes." Blood 76(3):455-462 (1990).
Ganser et al. "Effects of Recombinant Human Interleukin-3 in Patients with Normal Hematopoieses and in Patients with Bone Marrow Failure." Blood 76(4):666-676 (1990).
Ganser et al. "Effects of Recombinant Human Interleukin-3 in Aplastic Anemia." Blood 76(7):1287-1292 (1990).
Park et al. "Interleukin-3, GM-CSF, and G-CSF Receptor Expression on Cell Lines and Primary Leukemia Cells: Receptor Heterogeneity and Relationship to Growth Factor Responsiveness." Blood 74(1):56-65 (1989).
Sassenfeld Helmut M.
Urdal David L.
Draper Garnette D.
Hallquist Scott G.
Perkins Patricia Anne
Wight Christopher L.
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