Nonglycosylated analogs of human colony stimulating factors

Details Nonglycosylated analogs of human colony stimulating factors Nonglycosylated analogs of human colony stimulating factors

1986-10-14

1991-07-16

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

530350, 530395, 530820, 530824, 435 691, 435 695, 435 696, 935 49, 935 50, C07K 1300

Patent

active

050326767

ABSTRACT:
An analog human colony stimulating factor (hCSF) is disclosed, comprising a mutant amino acid sequence which is substantially homologous to the native sequence of an hCSF having at least one N-glycosylation site, wherein the mutant sequence comprises at least one amino acid substitution, deletion or insertion inactivating the N-glycosylation site.

REFERENCES:
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Dietz, J. Clin. Invest. 79, 1987, pp. 1549-1557.
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