Nonenzymatic glucose test

Details Nonenzymatic glucose test Nonenzymatic glucose test

1988-10-13

1992-05-26

Warden, Robert J.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-o

422 56, 422 57, 435 14, 436163, 427 2, 427395, G01N 3352

Patent

active

051167638

ABSTRACT:
The invention provides a nonenzymatic method useful for the semiquantitative determination of glucose, a test composition and test device. Glucose concentration in an aqueous test sample can be determined by preparing a test solution by contacting an aqueous test sample and a dihydroxide component, at an initial pH above 6.5, capable of forming a complex with glucose which complex formation releases a proton, and determining the final pH of the test solution. The invention also provides a self-indicating device format which allows the determination of glucose concentration by merely counting the number of pads which have changed color. No comparison to a color chart is required. The glucose test of the present invention is free of the interferences found in enzymatic glucose tests.

REFERENCES:
patent: 3964871 (1976-06-01), Hochstrasser
patent: 4288541 (1981-09-01), Magers et al.
Paal, Chem. Abst., vol. 95, 1981, No. 95:31046k.
Boruch et al., Chem. Abst., vol. 90, 1979, No. 90:23428t.
Lapenko, Chem. Abst., vol. 78, 1973, No. 78:98334v.
Britton, "Hydrogen Ions-Their Determination and Importance in Pure and Industrial Chem.", vol. II, P. Van Nostrand Co., Inc. New York, 1943, pp. 172-173.

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