Nonapeptides and methods for their production

Details Nonapeptides and methods for their production Nonapeptides and methods for their production

1976-12-27

1978-04-25

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 424177, C07C10352, A61K 3700

Patent

active

040862194

ABSTRACT:
New nonapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R.sub.2 -Leu-Arg-Pro-Gly-R.sub.3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R.sub.2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro or D-Asn and R.sub.3 is NH.sub.2, NH(lower alkyl) or N-(lower alkyl).sub.2, methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said nonapeptides as luteinizing hormone releasing factor antagonists.

REFERENCES:
patent: 3914412 (1975-10-01), Gerdrick et al.
patent: 3937695 (1976-02-01), Sarantakis
patent: 4016259 (1977-04-01), Kent, Jr.
E. Schroeder et al., "The Peptides," I, Academic Press, N.Y., 1965, pp. 22-30, 79-80.

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