Nonapeptide bombesin antagonists

Details Nonapeptide bombesin antagonists Nonapeptide bombesin antagonists

1990-11-29

1993-09-14

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530327, 530328, 514 14, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

052448835

ABSTRACT:
The novel pseudo polypeptides of this invention are potent bombesin antagonists. There are provided processes for their production, pharmaceutical compositions comprising said polypeptides and their use as pharmaceutically active agents. More particularly the present invention provides pseudopeptides comprising a nonapeptide moiety of formula I:

REFERENCES:
Coy et al., J. of Biol. Chem., vol. 264, No. 25, pp. 14691-14697, Sep. 1989.
Coy et al., J. Biol. Chem., vol. 263, No. 11, pp. 5056-5060, Apr. 1988.
Smith et al., Principles of Biochemistry 7th ed., edoted. Laufer et al., McGraw-Hill, New York, 1983.

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