Nona- and deca-peptide amide derivatives demonstrating high ovul

Details Nona- and deca-peptide amide derivatives demonstrating high ovul Nona- and deca-peptide amide derivatives demonstrating high ovul

1976-04-05

1978-12-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125LH, A61K 3702, C07C10352

Patent

active

041286383

ABSTRACT:
A peptide amide derivative of general formula (I) wherein when X is Gly, Y is Leu and Z is .beta.-Ala-NH.sub.2 or Sar-NH.sub.2 ; when X is D-Ala, Y is Leu, Ile, Nle, Val, Nval, or Met and Z is Gly-NH.sub.2, .beta.-Ala-NH.sub.2 or Sar-NH.sub.2, provided that when X is D-Ala and Y is Leu Z is not Gly-NH.sub.2 ; and when X is .beta.-Ala, Y is Leu, Ile, Nle, Val, Nval or Met and Z is Gly-NH.sub.2, .beta.-Ala-NH.sub.2, Sar-NH.sub.2 or -NRR' wherein R and R', which may be the same or different, are H, lower alkyl containing from 1 to 6 carbon atoms, substituted lower alkyl containing from 1 to 6 carbon atoms, or together may form a ring; or a pharmaceutically acceptable acid-addition salt or metal-ion complex thereof; and an inert carrier therefor.

REFERENCES:
patent: 3941763 (1976-03-01), Sarantakis
patent: 3972859 (1976-08-01), Fujino et al.
Ling, et al., Biochem. and Biophys. Res. Comm. 63, 1975, pp. 801-806.
Hirotsu, et al., Biochem. and Biophys. Res. Comm. 59, 1974, pp. 277-282.
Fujino, et al., Biochem. and Biophys. Res. Comm. 60, 1974, pp. 406-413.
White, Annual Reports in Medical Chemistry, vol. 8, 1973, pp. 204-213.
M. Fujino et al., Biochemical & Biophysical Research Comm., vol. 49, No. 3, 1972, pp. 698-705.

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