Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Wearing apparel – fabric – or cloth
Patent
1998-01-29
1999-11-30
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Wearing apparel, fabric, or cloth
424405, 424409, 424414, A01N 2534
Patent
active
059938404
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a composition comprising a non-woven material treated with polymeric biguanides and an anionic polymer and the use of such composition in disposable articles such as nappies, incontinence pads and feminine hygiene packs.
EP 174,128 discloses a disposable article such as a nappy, incontinence pad or feminine hygiene pack which is formed from a non-woven material treated with a mixture of linear polymeric biguanides having different molecular weights. These biguanides inhibit microbial growth in the article during use and in the case of nappies, especially, the use of the non-woven material containing the polymeric biguanides is said to reduce odours and provide protection against nappy rash or ammonia dermatitis. The linear polymeric biguanides are also said to be particularly useful for treating the non-woven material, especially cellulosic non-woven material, which is used as an absorbent layer in disposable articles because of their broad spectrum of microbiological activity, low toxicity and ease of application. The linear polymeric biguanides are adsorbed strongly by the cellulosic non-woven material and are easily applied uniformly throughout such material.
It has been found that when the non-woven material containing the polymeric biguanides is wetted with urine, as occurs during use of a disposable article such as a nappy or incontinence pad, some of the polymeric biguanides are desorbed. This desorption of polymeric biguanides is generally less than 20% by weight of that applied and is believed to be primarily the lower molecular weight fractions of the mixture of polymeric biguanides applied. This can lead to concentration gradients of polymeric biguanides within the non-woven material whereby the antimicrobial protection conferred by the polymeric biguanides is reduced in some regions below an effective level. It is also possible that the polymeric biguanides which are desorbed by urine may be removed from the locus of the non-woven material and hence no longer available to inhibit microbial growth within such material.
It has also been found that the polymeric biguanides which are desorbed from the non-woven material on contact with urine can be retained within the non-woven material by including an anionic polymer in admixture with the non-woven material and that the presence of the anionic polymer has no significant detrimental effect on the microbiological efficacy of the polymeric biguanides.
Thus, according to the present invention there is provided a composition comprising
a) a non-woven material containing a mixture of polymeric biguanides; and
b) an anionic polymer.
The non-woven material is preferably fibrous and may be any material suitable for use as the absorbent layer in disposable articles such as nappies, incontinence pads and feminine hygiene packs. Preferably, the fibres of the fibrous material have an average diameter from 1 to 200.mu. and especially from 10 to 100.mu.. Generally, the fibres are at least 1 mm in length. The fibres may be wet- or dry-laid and are preferably dry-laid to form a highly fluffed absorbent layer.
Examples of fibrous non-woven material are cellulose, modified cellulose and rayon. Other suitable fibrous non-woven materials are hydrophobic fibres which are treated with a wetting agent. Examples of such hydrophobic fibres are polyolefins such as polyethylene and polypropylene, polyacrylamide, polyester such as polyethylene teraphthalate, polyamide, polystyrene and polyurethane.
The non-woven material is preferably cellulose and especially wood pulp fibre which is optionally chemically modified by chemically cross-linking with a C.sub.2-8 -dialdehyde to give an average water retention value of from 28 to 50% by weight. Preferred wood pulp fibres are these generally known as semi-chemical wood pulps and especially chemical wood pulps such as those obtainable from sulphite or Kraft processes.
The individual polymers of the mixture of polymeric biguanides contain at least one recurring unit having two biguanide groups of Formu
Fawkes David Melville
Payne John David
Clardy S. Mark
Shelborne Kathryne E.
Zeneca Limited
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