Non-traumatic model for neurogenic pain

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C800S008000, C800S003000, C514S021800

Reexamination Certificate

active

07388124

ABSTRACT:
A method for producing a non-human mammalian model for neurogenic pain is provided, which includes altering a peripheral nerve of a non-human mammal by non-surgically placing a gel substance into the fascial tunnel through which the peripheral nerve passes. The placement of the gel substance leads to one or more pain behaviors thereby producing the pain model. Also provided is a non-human mammalian model for neurogenic pain so produced. Further provided is a method for screening a treatment or a therapeutic agent for efficacy in treating neurogenic pain as well as a method for screening an analgesic agent for analgesic effect in neurogenic pain.

REFERENCES:
Field, MJ et al, 1999, Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain:are they signalled by distinct primary neurons, Pain, 83:303-311.
LoPinto, C et al, 2006, Cepalagia, 26:852-856.
Wang, L.X. 2003, Animal and cellular models of chronix pain. Adv. Drug Deliv. Rev. vol. 55, pp. 949-965.
Petersen, K.L. 2001, Effect of remifentanil on pain and secondary hyperalgesis associated with the heat-capsaicin sinsitization model in healthy volunteers, Anesthesiology, vol. 94, pp. 15-20.
Lublin, J. 1998, Carpal tunnel syndrome: a review of initial diagnosis and treatment for the OB/GYN, Prim Care Update Ob/Gyns, vol. 5, pp. 280-285.
Eliav, E., 1999, Neuropathic pain from an experimental neuritis of the rat sciatic nerve, Pain, vol. 83, pp. 169-182.
Keeton, W and Gould, J., Biological Science, 4th edition, W.W. Norton and Company, paragraph bridging pp. 458-459, 1986.
Lundborg, G. 1982, Median nerve compression in the carpal tunnel-Functional response to experimentally induced controlled pressure, Journal of Hand Surgery, vol. 1, pp. 252-259.
Wall, 1996, “Transgenic Livestock: Progress and Prospects for the Future”, Theriogenology, vol. 45, pp. 57-68.
Houdebine, 1994, “Production of Pharmaceutical Proteins from Transgenic Animals”, J. Biotech. vol. 34, pp. 269-287.
Reyna, 1999, “Biogenic Animal Model of Chronic Pain: A Nontraumatic Model”, ICLAS, Palma de Malloren, May 26-28, p. 226.
Ford, 1986, “Histologic Studies on the Fate of Soluble Collagen Injected into Canine Vocal folds”, Laryngoscope, vol. 96, pp. 1248-1257.
Allodynia, Stedman's Medical Dictionary, online http://www.stednians.com, 2008 http://216.251.232.159/semdweb/internetsomd/ASP/1526727.asp.
Hyperalgesia, Stedman's Medical Dictionary,online http://www.stedmans.com, 2008.
Moss et al. 2002, “A Role of the Ubiquitin-Proteasome System in Neuropathic Pain”, J. of Neuroscience, 22(4):1363-1372.
Reeve et al. 1998, “Spinal Effects of Bicuculline: Modulation of an Allodynia-Like State by an A1-Receptor Agonist, Morphine, and an NMDA-Receptor Antagonist”, J. Neurophysiol., 79(3):1494-1507.
Suzuki et al., 2004, “ReN-1869 [(R)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine Carboxylic Acid], a Novel Histamine H1 Receptor Antagonist, Produces Potent and Selective Antinociceptive Effects on Dorsal Horn Neurons after Inflammation and Neuropathy”, Pharmacol Exp Ther., 309(3):1230-1238.
Senapati et al. 2005, “Electrical Stimulation of the Anterior Cigulate Cortex Reduces Responses of Rat Dorsal Horn Neurons to Mechanical Stimuli”, J Neurophysiol., 94(1):845-851.
Zhuo and Gebhart, 2002, “Modulation of Noxious and Non-Noxious Spinal Mechanical Transmission From the Rostral Medial Medulla in the Rat”, J Neurophysiol., 88(6):2928-41.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Non-traumatic model for neurogenic pain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-traumatic model for neurogenic pain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-traumatic model for neurogenic pain will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2808775

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.