Non-toxinogenic vibrio cholerae mutants

Details Non-toxinogenic vibrio cholerae mutants Non-toxinogenic vibrio cholerae mutants

1983-04-29

1989-11-21

Huleatt, Jayme A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352521, 4352523, 435320, 435909, 935 29, 935 56, 935 65, 935 72, C12N 1500, C12N 120, C12R 163

Patent

active

048822787

ABSTRACT:
A genetically stable nontoxinogenic form of the Ogawa 395 strain of Vibrio cholerae which has a deletion mutation in both copies of the A.sub.1 -peptide-encoding gene, resulting in the loss of a gene sequence required for expression of a toxic A.sub.1 peptide is disclosed, as well as plasmids and methods for making the strain. The strain is useful as a live or dead oral vaccine.

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