Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2006-12-12
2006-12-12
Navarro, Mark (Department: 1645)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Reexamination Certificate
active
07148065
ABSTRACT:
Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced toxicity compared to the corresponding unmodified native toxin. The native pyrogenic toxins are typically modified by deletions within the disulfide loop region to produce modified enterotoxins having 100-fold or greater decrease in toxicity.
REFERENCES:
patent: 4172126 (1979-10-01), Okonogi et al.
patent: 5885780 (1999-03-01), Olivera et al.
patent: 6075119 (2000-06-01), Bannan et al.
patent: WO 91/10680 (1991-07-01), None
patent: WO 93/24136 (1993-12-01), None
patent: WO 96/40930 (1996-12-01), None
patent: WO 97/36932 (1997-10-01), None
patent: WO 98/24910 (1998-06-01), None
patent: WO 98/24911 (1998-06-01), None
Alakhov, V. et al., “Identification of Functionally Active Fragments of Staphylococcal Enterotoxin B”,Eur. J. Biochem., vol. 209, pp. 823-828 (Feb. 1992).
Bayles, K. et al., “Genetic and Molecular Analyses of the Gene Encoding Staphylococcal Enterotoxin D”,Journal of Bacteriology, vol. 171, No. 9, pp. 4799-4806 (Sep. 1989).
Binek, M. et al., “Localisation of the Mitogenic Epitope of Staphylococcal Enterotoxin B”,J. Med. Microbiol., vol. 36, pp. 156-163 (1992).
Bohach, G. et al., “Expression of Staphylococcal Enterotoxin C1inEscherichia coli”, Infection and Immunity, vol. 55, No. 2, pp. 428-432 (Feb. 1987).
Bonventre, P. et al., “A Mutation at Histidine Residue 135 of Toxic Shock Syndrome Toxin Yields an Immunogenic Protein with Minimal Toxicity”,Infection and Immunity, vol. 63, No. 2, pp. 509-515 (Feb. 1995).
Couch, J. et al., “Cloning and Nucleotide Sequence of the Type E Staphylococcal Enterotoxin Gene”,Journal of Bacteriology, vol. 170, No. 7, pp. 2954-2960 (Jul. 1988).
Hovde, C. et al., “Investigation of the Role of Disulphide Bond in the Activity and Structure of Staphylococcal Enterotoxin C1”,Molecular Microbiology, vol. 13, No. 5, pp. 897-909 (1994).
Liu, C.T. et al., “Effect of Staphylococcal Enterotoxin B on Cardiorenal Functions in Rhesus Macaques”, American Journal ofVeterninary Research, vol. 39, No. 2, pp. 279-286 (Feb. 1978).
Liu, C.T. et al., “Effect of Staphylococcal Enterotoxin B on Cardiorenal Functions and Survival in X-Irradiated Rhesus Macaques”, American Journal ofVeterninary Research, vol. 39, No. 7, pp. 1213-1217 (Jul. 1978).
Leung, D. et al., “Bacterial Superantigens Induce T Cell Expression of the Skin-selective Homing Receptor, the Cutaneous Lymphocyte-associated Antigen, via Stimulation of Interleukin 12 Production”,Journal of Experimental Medicine, vol. 181, No. 2, pp. 747-753, (Feb. 1995).
Nishi, J. et al., “B Cell Epitope Mapping of the Bacterial Superantigen Staphylococcal Enterotoxin B”,The American Association of Immunologists© , pp. 247-254 (1997).
Reda, K. et al., “Molecular Characterization and Phylogenetic Distribution of the Streptococcal Superantigen Gene (ssa) from Streptococcus pyogenes”,Infection and Immunity, vol. 62, No. 5, pp. 1867-1874, (May 1994).
Bergdoll, M., “Monkey Feeding Test for Staphylococcal Enterotoxin”, Methods Enzymol., vol. 165, 1988, p. 324-333.
Bohach, et al., “Cross-Neutralization of Staphylococcal and Streptococcal Pyrogenic Toxins by Monoclonal and Polyclonal Antibodies”, Infect. Immun., vol. 56, No. 2, 1988, p. 400-404.
Bohach, et al., “Staphylococcal and Streptococcal Pyrogentic Toxins Involved in Toxic Shock Syndrome and Related Illnesses”, Crit Rev Microbiol, vol. 17, No. 4, 1990, p. 251-272.
Bohach, et al., “Staphylococci in Human Disease”, K. B. Crossley and GI.L. Archer (ed.), Churchhill Livingstone NY, 1997, p. 83-111.
Bohach, et al., “The Staphlococcal and Streptococcal Pyrogenic Toxin Family”, in B.R. Singh and A.T. Tu(ed), Natural Toxins II, Plenum Press, New York, p. 131-154.
Grossman, et al., “Dissociation of the Simulatory Activities of Staphylococcal Enterotoxins for T Cells and Monocytes”, J Exp Med, vol. 172, No. 6, Dec. 1, 1990, p. 1831-1841.
Grossman, et al., “Mutation of the Disulfide Loop in Staphylococcal Entertoxin A”, J. Immunol, vol. 147, No. 10, Nov. 15, 1991, p. 3274-3271.
Hoffmann, et al., “Predictions of T-Cell Receptor and Major Histocompatibility Complex-Binding Sites on Staphylococcal Enterotoxin C1”, Infect Immun., vol. 62, No. 8, Aug. 1994, p. 3396-3407.
Hovde, et al., “Nucleotide sequence of the staphylococcal enterotoxin C3 gene: Sequence comparison of all three Type C staphylococcal enterotoxins”, Molecular & General Genetics, vol. 220, No. 2, Jan. 1990, p. 329-333.
Kappler, et al., “Mutations Defining Functional Region of the Superantigen Staphylococcal Enterotoxin B”, J Exp Med., vol. 175, No. 2, Feb. 1, 1992, p. 387-397.
Kim, et al., “A Purified Group A Streptococcal Pyrogenic Exotxin”, J Exp Med, vol. 131, No. 3, Mar. 1, 1970, p. 611-622.
Kline, et al., “Analysis of the Superantigenic Activity of Mutant and Allelic Forms of Streptococcal Pyrogenic Exotoxin A”, Infection and Immunity, vol. 64, No. 3, Mar. 1996, p. 861-869.
Poindexter, et al., “Binding of Toxic-Shock-Syndrome Toxin-1 to Human Peripheral Blood Mononuclear Cells”, J Infect Dis., vol. 156, No. 1, Jul. 1987, p. 122-129.
Roggiani, et al., “Analysis of Toxicity of Streptococcal Pyrogenic Exotoxin”, Infection and Immunity, vol. 65, No. 7, Jul. 1997, p. 2868-2875.
Schlievert, et al., “Purification and Characterization of Group A Streptococcal Pyrogenic Exotoxin Type C”, Infect Immun., vol. 16, No. 2, May 1977, p. 673-679.
Schlievert, P.M., “Enhancement of Host Susceptibility to Lethal Endotoxin Shock by Staphylococcal Pyrogenic Exotoxin Type C”, Infect. Immun., vol. 36, No. 1, Apr. 1982, p. 123-128.
Idaho Research Foundation Inc.
Merchant & Gould P.C.
Navarro Mark
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