Non-toxic double mutant forms of pertussis toxin as adjuvants

Details Non-toxic double mutant forms of pertussis toxin as adjuvants Non-toxic double mutant forms of pertussis toxin as adjuvants

2007-01-30

2007-01-30

Duffy, Patricia A. (Department: 1645)

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

C424S278100, C424S094100, C424S184100

Reexamination Certificate

active

09775909

ABSTRACT:
The invention relates to the use of an antigen which is a non-toxic double mutant form of pertussis toxin for the manufacture of a vaccine composition for intranasal administration to induce an immune response againstB. pertussisinfection. The invention also relates to the use of a non-toxic double mutant form of pertussis toxin for the manufacture of an adjuvant composition for stimulating or enhancing a protective immune response of an antigen co-administered therewith. The non-toxic double mutant is preferably one in which the glutamic acid 129 amino acid in the S1sub-unit has been substituted by glycine and the arginine 9 amino acid has been substituted by lysine.

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