Non-thrombogenic coating composition and methods for using same

Details Non-thrombogenic coating composition and methods for using same Non-thrombogenic coating composition and methods for using same

1998-09-22

1999-09-21

Fonda, Kathleen K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 56, 523112, 604266, 427 21, 427 224, 427 225, 427 23, C08B 3710, A01N 100, A61M 532, A61L 3300

Patent

active

059555882

ABSTRACT:
The present invention provides an anti-thrombogenic coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: ##STR1## wherein R.sub.1 is a C.sub.1-8 alkyl or C.sub.6-32 aryl group, each R.sub.2 is independently selected from the group consisting of C.sub.1-8 alkyl and C.sub.6-32 aryl, R.sub.3 is N or O, and n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding.

REFERENCES:
patent: 5338770 (1994-08-01), Winters et al.
patent: 5463010 (1995-10-01), Hu et al.
patent: 5541167 (1996-07-01), Hsu et al.
Kim et al. Journal of Applied Polymer Science 1994, 54(12), 1863-72.

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