Non-thrombogenic and anti-thrombogenic polymers

Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer

Reexamination Certificate

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Details

C514S002600, C514S056000, C526S286000, C526S287000, C526S320000, C526S333000, C424S078180, C424S078310, C424S078350, C424S078370

Reexamination Certificate

active

07034061

ABSTRACT:
Polymers having non-thrombogenic properties can be prepared by copolymerizing monomers of at least three classes selected from (a) monomers having sulphate groups, (b) monomers having sulphonate groups, (c) monomers having sulphamate groups, (d) monomers having polyoxyalkylene ether groups, and (e) monomers having zwitterionic groups. The polymers can additionally be provided with anti-thrombogenic properties by including an additional comonomer having a pendant heparin (or hirudin, warfarin or hyaluronic acid) group. The polymers can be used as coating materials for medical devices, such as tubing or connectors, in order to provide them with non-thrombogenic, and optionally anti-thrombogenic, properties.

REFERENCES:
patent: 3086956 (1963-04-01), Armen et al.
patent: 4200563 (1980-04-01), Komiya
patent: 5858296 (1999-01-01), Domb
patent: 5945457 (1999-08-01), Plate et al.
patent: 6096798 (2000-08-01), Luthra et al.
patent: 6406687 (2002-06-01), Luthra et al.
patent: 0 124 676 (1984-11-01), None
patent: WO 91/16932 (1991-11-01), None
Heparin Derivatives of High Molecular Weight,by Mester, Amaya and Mester.Carbohydrate Sulfates, (1978) 113-120.

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