Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as

Details Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as Non-symmetrical bis-heteroarylmethoxyphenylalkyl carboxylates as

1996-07-26

1997-09-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546174, 546175, 546176, 546153, 546180, A61K 3147, A61K 31475, C07D21514, C07D21518

Patent

active

056681500

ABSTRACT:
Compounds having the formula ##STR1## wherein W and Y are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, and optionally substituted naphthyl with the proviso that W and Y are not simultaneously the same substituent; R.sup.1 and R.sup.2 are independently hydrogen, alkyl, haloalkyl, alkoxy, or halogen; R.sup.3 is hydrogen or alkyl; X is absent or is alkylene, alkenylene, or alkynylene; and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.4 wherein R.sup.4 is hydrogen or alkyl; and (c) --NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 are independently selected from hydrogen, alkyl, hydroxy and alkoxy are disclosed. These compounds inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.

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Musser, J.H., et al., "5-Lipoxygenase: Properties, Pharmacology, and the Quinolinyl(bridged)aryl Class of Inhibitors", Journal of Medicinal Chemistry, 35(14):2501-2523 (1992).
Prasit, P., et al.., "A New Class of Leukotriene Biosynthesis Inhibitors: The Develoment of ((4-(4-Chlorophenyl)-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid, L-674,636", Bioorganic & Medicinal Chemistry Letters, 1(11):645-648 (1991).

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