Non-steroidal suicide substrates of hydroxysteroid dehydrogenase

Details Non-steroidal suicide substrates of hydroxysteroid dehydrogenase Non-steroidal suicide substrates of hydroxysteroid dehydrogenase

1990-06-18

1992-06-02

Patterson, Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435190, C12N 999, C12N 904

Patent

active

051186217

ABSTRACT:
Compounds, such as 1-(4'-nitrophenyl)-2-propen-1-ol, are disclosed which are highly selective non-steroidal suicide substrates for rat liver 3.alpha.-hydroxysteroid dehydrogenase.

REFERENCES:
Penning, et al. (1984) Biochem. J. 222, 601-611.
Penning, et al. (1983) Proc. Natl. Acad. Sci., U.S.A. 80, 4504-4508.
Penning, et al. (1987) Biochem. Biophys. Res. Comm. 148 (2), 646-652.

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