Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-04-01
2010-06-15
Coleman, Brenda L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S546000
Reexamination Certificate
active
07737136
ABSTRACT:
The present invention provides compounds according to general Formula (I), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a prodrug thereof. More particularly, the present invention provides high affinity non-steroidal compounds which are agonists, partial agonists or antagonists of the progesterone receptor.
REFERENCES:
patent: 3966723 (1976-06-01), van der Burg
patent: 4016161 (1977-04-01), Van der Burg
patent: 4054572 (1977-10-01), van der Burg
patent: 5688810 (1997-11-01), Jones et al.
patent: 2420168 (1974-04-01), None
patent: 0 421 802 (1991-04-01), None
patent: 0 303 306 (1993-03-01), None
patent: 0 876815 (1998-11-01), None
patent: WO 03/084963 (2003-10-01), None
patent: WO 2006/084917 (2006-08-01), None
patent: WO 2008/037746 (2008-04-01), None
Beato et.al., “DNA Regulatory Elements for Steroid Hormones,”J. Steroid Biochem. 32 (1989) 737-747.
Caufield, W., “Synthesis of 1-amino-1,2,3,14b-tetrahydro-4H-pyrido[1,2-d]-dibenzo[b,f] [1,4]oxazepine and related compounds”,J. Chem. Soc., Perkins Trans. 1, No. 6, pp. 545-553, (1996).
Dijkema, R., et al., “Human Progesterone Receptor A and B Isoforms in CHO cells. I. Stable Transfection of Receptor and Receptor-responsive Reporter Genes: Transcription Modulation by (Anti)progestagens”,J. Steroid Biochem. Biol., vol. 64, No. 3-4, pp. 147-156 (1998).
Schoonen, W., et al., “Development of High-Throughput in Vitro Bioassay to Assess Potencies of Progestagenic Compounds Using Chinese Hamster Ovary Cells Stably Transfected with the Human Progesterone Receptor and a Luciferase Reporter System”,Analytical Biochemistry, vol. 261, pp. 222-224 (1998).
PCT International Search Report dated, Aug. 6, 2003, for corresponding PCT Application No. PCT/EP03/50085.
PCT International Search Report and Written Opinion, dated Aug. 12, 2008, which was issued during the prosecution of International Application No. PCT/EP2008/003714, which is related to the present application.
PCT International Search Report and Written Opinion, dated Dec. 28, 2007, which was issued during the prosecution of International Application No. PCT/EP2007/060225, which is related to the present application.
Dols Paul Peter Marie Antonius
Folmer Brigitte Johanna Bernita
Hermkens Pedro Harold Han
Lucas Hans
Rewinkel Johannes Bernardus Maria
Coleman Brenda L
Hess Susan L.
N.V. Organon
LandOfFree
Non-steroidal progesterone receptor modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-steroidal progesterone receptor modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-steroidal progesterone receptor modulators will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4159505