Non-steroidal antiinflammtory drug formulations for topical appl

Details Non-steroidal antiinflammtory drug formulations for topical appl Non-steroidal antiinflammtory drug formulations for topical appl

1997-08-29

1999-11-02

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424484, 514944, 514946, A61K 4710, A61K 4722, A61K 910

Patent

active

059765666

ABSTRACT:
Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as, naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

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Press Release, Lexington, MA, September 19, 1995 -MacroChem Corp.
Press Release, Lexington, MA, July 16, 1996 -MacroChem Corp.
L.C. Fuhrman, et al., Studies of In Vitro (Trans)Dermal Absorption . . . , Prediction of Percutaneous Penetration, vol. 4B, pp. 117-126, 1996.
Marty, et al., Effect of Dioxolanes On Indomethacin In Vitro . . . , Proceed. Intern. Symp. Control. rel. Bioact. Mater., 16, 179, 1989.

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