Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1997-03-28
1999-04-06
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424426, 424502, 435180, 435182, A61F 202, A61K 950, C12N 1104, C12N 1108
Patent
active
058914773
ABSTRACT:
Methods for inhibition of fibrotic rejection of implanted devices which contain cells by administering to the recipient of the devices an amount of a non-steroidal anti-inflammatory agent (NSAID) sufficient to inhibit fibrotic inactivation of the device. Most NSAID's are carboxylic acids (R--COOH) or enolic acids (R--COH).
REFERENCES:
Wong, H. et al., "The Microencapsulation of Cells Within Alginate Poly-L-Lysine Microcapsules Prepared with the Standard Single Step Drop Technique: Histologically Identified Membrane Imperfections and the Associated Graft Rejection", Biomat. Art. Cells & Immob. Biotech., vol. 19 (4), pp. 675-686 (1991).
Young, D., "Inverted Microcarriers: Using Microencapsulation to Grow Anchorage-Dependent Cells", Fundamentals of Animal Cell Encapsulation and Immobilization, CRC Press, Chapter 11, pp. 243-265 (1993).
Young, D. et al., "Inverted Microcarriers Using Microencapsulation to Grow Anchorage-Dependent Cells in Suspension", Biopharm, vol. 2, pp. 34-46 (1989).
Chick William L.
Lanza Robert P.
Azpuru Carlos A.
BioHybrid Technologies, Inc.
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