Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1994-09-08
1998-09-15
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
546192, 549356, 514542, C07C 6976
Patent
active
058081399
ABSTRACT:
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
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Berger Christina S.
Farmer Luc
Fenical William
Hamann Lawrence G.
Johnson Michael G.
Geist Gary
Ligand Pharmaceuticals Incorporated
Padmanabhan Sreeni
The Regents of the University of California
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