Non-steroid and non-prostanoid inhibitors of steroid and prostag

Details Non-steroid and non-prostanoid inhibitors of steroid and prostag Non-steroid and non-prostanoid inhibitors of steroid and prostag

1991-09-09

1993-11-02

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435190, C12N 999, C12N 904

Patent

active

052582965

ABSTRACT:
Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).

REFERENCES:
MacInnes, et al., Allylic Inhibitors of Alcohol Dehydrogenase, Journal of the Chemical Society Perkin Transaction 1, 1981, 1103-1108.
Covey, et al., Biochemistry 1986, 25, 7288.
Lawate and Covey, J. Med. Chem. 1990, 33, 2319-2321.
Ricigliano et al., Biochem. J. 1989, 262, 139.

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